Adenomyomatosis of the gallbladder is a hyperplastic cholecystosis of the gallbladder wall. It is a relatively common and benign cause of diffuse or focal gallbladder wall thickening. It is most easily seen on ultrasound and MRI.
Adenomyomatosis is relatively common, found in ~9% of all cholecystectomy specimens 5. It is typically seen in patients in their 5th decade. The incidence increases with age which may be the result of protracted inflammation (see below). There is a female predilection (M:F=1:3).
It is most often an incidental finding, has no intrinsic malignant potential, and usually requires no treatment. It may be found more often in chronically inflamed gallbladders (which are at higher risk for carcinoma), but it is not a premalignant lesion 5.
Adenomyomatosis per se is usually asymptomatic. It is however frequently associated with chronic biliary inflammation, most commonly gallstones (25-75%) but also seen in cholesterolosis (33%) and pancreatitis 2.
Adenomyomatosis is one of the hyperplastic cholecystoses. There is hyperplasia of the wall with formation of intramural mucosal diverticula (Rokitansky-Aschoff sinuses) penetrating into the muscular wall of the gallbladder, with or without gallbladder wall thickening. Cholesterol accumulation in adenomyomatosis is intraluminal, as cholesterol crystals precipitate in the bile trapped in Rokitansky-Aschoff sinuses (intramural diverticula lined by mucosal epithelium).
Three morphological types of adenomyomatosis are described:
- fundal (localised)
- segmental (annular)
- generalised (diffuse)
- mural thickening (diffuse, focal, annular)
- segmental/annular form is especially difficult to distinguish from gallbladder carcinoma
- comet-tail artifact: echogenic intramural foci from which emanate V-shaped comet tail reverberation artifacts are highly specific for adenomyomatosis, representing the unique acoustic signature of cholesterol crystals within the lumina of Rokitansky-Aschoff sinuses 4
- abnormal gallbladder wall thickening and enhancement are common but nonspecific CT features of adenomyomatosis
- Rokitansky-Aschoff sinuses of sufficient size can be visualized; a CT rosary sign has been described, formed by enhancing epithelium within intramural diverticula surrounded by the relatively unenhanced hypertrophied gallbladder muscularis
MRCP (or oral cholecystography)
Historically oral cholecystograms were performed, however, due to low sensitivity and a high rate of contrast allergies it has now largely been replaced by MRCP which does not rely on contrast opacification of the lumen of the gallbladder. MRCP is also able to detect:
- mural thickening
- focal sessile mass
- pearl necklace sign (fluid filled intramural diverticula)
- hourglass configuration in annular types
- pearl necklace sign refers to the characteristically curvilinear arrangement of multiple rounded hyperintense intraluminal cavities visualized at T2-weighted MR imaging and MRCP 4
- metabolic characterisation with PET has been suggested as a useful adjunct in problematic cases 4, but there have also been cases with increased uptake in areas of adenomyomatosis, leading to false positive results 6
Treatment and prognosis
Cholecystectomy may be performed as a result of one or more of the following:
- patient symptomatic with right upper quadrant pain (often due to gallstones)
- appearances (especially when focal) may be difficult to distinguish from malignancy
General imaging differential considerations include:
Exclusion of gallbladder cancer may be most problematic in segmental and focal cases. Focal adenomyomatosis may appear as a discrete mass, known as an adenomyoma.
Ultrasound - gallbladder
- ultrasound (introduction)
- gallbladder ultrasound
- diffuse gallbladder wall thickening (differential)
- focal gallbladder wall thickening (differential)
- gallbladder sludge
- acute cholecystitis
- chronic cholecystitis
- gallbladder polyp
- porcelain gallbladder
- gallbladder carcinoma
- gallbladder metastases
- gallbladder lymphoma
- gallbladder volvulus / torsion
- variants and anomalies
- 1. Haradome H, Ichikawa T, Sou H et-al. The pearl necklace sign: an imaging sign of adenomyomatosis of the gallbladder at MR cholangiopancreatography. Radiology. 2003;227 (1): 80-8. doi:10.1148/radiol.2271011378 - Pubmed citation
- 2. JC Balaguera et al “ISPUB - Diffuse Adenomyomatosis Of The Gallbladder: An Infrequent Disease With Difficult Preoperative Diagnosis.” [Link].
- 3. Ching BH, Yeh BM, Westphalen AC et-al. CT differentiation of adenomyomatosis and g allbladder cancer. AJR Am J Roentgenol. 2007;189 (1): 62-6. doi:10.2214/AJR.06.0866 - Pubmed citation
- 4. Boscak AR, Al-hawary M, Ramsburgh SR. Best cases from the AFIP: Adenomyomatosis of the gallbladder. Radiographics. 26 (3): 941-6. doi:10.1148/rg.263055180 - Pubmed citation
- 5. Mellnick VM, Menias CO, Sandrasegaran K et-al. Polypoid lesions of the gallbladder: disease spectrum with pathologic correlation. Radiographics. 2015;35 (2): 387-99. doi:10.1148/rg.352140095 - Pubmed citation
- 6. Maldjian PD, Ghesani N, Ahmed S et-al. Adenomyomatosis of the gallbladder: another cause for a "hot" gallbladder on 18F-FDG PET. AJR Am J Roentgenol. 2007;189 (1): W36-8. doi:10.2214/AJR.05.1284 - Pubmed citation