Adenomyosis of the uterus is a relatively common abnormality of the uterus. It is thought by many to be on the spectrum of endometriosis, and adenomyosis may present with menorrhagia and dysmenorrhea. Ultrasound and MRI are imaging modalities that may show characteristic findings.
Adenomyosis typically affects women of reproductive age. In general, affected women are multiparous, and the condition is seen with higher frequency in woman with a history of surgical uterine procedures (e.g. Caesarian section, dilatation and curettage). It has a reported incidence that ranges widely from 5 to 70%, depending on the histological definition used or the imaging modality used 12.
Most patients with adenomyosis are symptomatic and typically present with menorrhagia and dysmenorrhea. The ectopic endometrial glands within adenomyosis generally do not respond to cyclic ovarian hormones, unlike those of endometriosis.
Adenomyosis is histologically defined by the presence of ectopic endometrial tissue within the myometrium. Benign invasion of the myometrium by the endometrium also results in adjacent smooth muscle hyperplasia. It has been postulated that this dysfunctional hypertrophied muscular tissue surrounding the ectopic endometrial glands prevents uterine contractions from tamponading bleeding myometrial arterioles, hence these patients frequently present with dysfunctional uterine bleeding or menorrhagia.
In 20% of cases is associated with co-existent endometriosis 1.
Imaging features are variable and in many instances very subtle. Three (some say four) forms can be distinguished:
- diffuse adenomyosis: most common
- focal adenomyosis and adenomyoma: some consider these as separate (see below)
- cystic adenomyosis and adenomyotic cyst: rare
Adenomyosis is usually relatively generalised, affecting large portions of the uterus (typically the posterior wall), but sparing the cervix. Despite often marked enlargement of the uterus, the overall contour is usually preserved 5.
In some cases adenomyosis may be localised, forming a mass. In such cases the term adenomyoma may be used, although there appears to be some disagreement about whether the terms focal adenomyosis and adenomyoma refer to exactly the same entity (please refer to the article on adenomyoma for further discussion).
A rare variant is cystic adenomyosis which is believed to be the result of repeated focal haemorrhages resulting in cystic spaces filled with altered blood products 5.
Ultrasound is usually the first and often the only imaging modality employed to investigate menorrhagia and dysmenorrhea. Unfortunately, the sonographic features of adenomyosis are variable, and may be absent. The reported sensitivity and specificity of trans-abdominal ultrasound are 32-63% and 95-97% respectively 7.
The spectrum of findings includes:
- normal appearing uterus
- focal or diffuse bulkiness, typically of the posterior wall 5
- heterogeneous echogenicity (heterogenous myometrial echotexture) 1-2
- hyperechoic: islands of endometrial glands
- hypoechoic: associated muscle hypertrophy
- a "venetian blind" appearance may be seen due to subendometrial echogenic linear striations and acoustic shadowing where endometrial tissues cause a hyperplastic reaction
- small myometrial cysts: sub endometrial cysts
- thickening of the transition zone can sometimes be visualized as a hypoechoic halo surrounding the endometrial layer of 12 mm or more thickness
- subendometrial echogenic linear striations
- subendometrial echogenic nodules
May show diverticula extending into the myometrium 3.
CT is unable to diagnose adenomyosis, but may suggest its presence when uterine enlargement is present. Distinguishing between adenomyosis and uterine fibroids on CT is difficult if not impossible, although presence of calcifications strongly favours the latter 5.
MRI is the modality of choice to diagnose and characterise adenomyosis, and T2 weighted images (sagittal and axial) are most useful. MRI has a sensitivity of 78-88% and a specificity of 67-93% 7.
The most easily recognised feature is thickening of the junctional zone of the uterus to more than 12 mm, either diffusely or focally (normal junctional zone measures no more than 5 mm) 5.
- typically a region of adenomyosis appears as an ill-defined ovoid/diffuse region of thickening, often with small high T2 signal regions representing small regions of cystic change
- the region may also have a striated appearance 5
- foci of high T1 signal are often seen, indicating menstrual haemorrhage into the ectopic endometrial tissues 7
T1 C+ (Gd)
- contrast enhanced MR evaluation is usually not indicated for evaluation of adenomyosis, however, if performed, it shows enhancement of the ectopic endometrial glands
Treatment and prognosis
Treatment depends on the severity of symptoms and the need to preserve fertility. In some instances, suppression of normal cyclical hormone-induced proliferation of endometrial tissue (e.g. GnRH agonist) is sufficient.
In women with severe symptoms not relieved medically, and in whom fertility is no longer desirable, a hysterectomy may be performed.
The differential depends on the macroscopic distribution of endometrial tissue.
For diffuse disease consider:
- normal uterus
- diffuse uterine leiomyomatosis
- myometrial contraction: transient finding
For focal disease (adenomyoma) consider:
uterine fibroma (leiomyoma)
- better defined than adenomyoma
- may have pseudocapsule of compressed adjacent myometrial tissue 5
Whether focal or diffuse, another potential differential is treatment of breast cancer with Tamoxifen which can lead to poorly defined endometrial hyperplasia and endometrial polyps that can mimic adenomyosis 4 (see: Tamoxifen associated endometrial changes).
- ultrasound (introduction)
- ultrasound physics
- basic physics
- pulse-echo imaging
- real-time imaging
- contrast-enhanced ultrasound
- Doppler imaging
- ultrasound artifacts
- biological effects of ultrasound
- history of ultrasound
- obstetric ultrasound
- first trimester
- ectopic pregnancy
- second trimester
- gynaecologic ultrasound
- peritoneal inclusion cyst
- vascular ultrasound
- breast ultrasound
- shoulder ultrasound
- elbow ultrasound
- wrist ultrasound
- hand ultrasound
- hip ultrasound
- knee ultrasound
- ankle/foot ultrasound
- paediatric musculoskeletal ultrasound
- skin/soft tissue ultrasound
- ultrasound of arthropathies
- liver ultrasound
- hepatic vasculature
- hepatic trauma on ultrasound
- liver transplant
- gallbladder ultrasound
- pancreas ultrasound
- pancreatic carcinoma
- pancreatic endocrine tumors / islet cell tumors
- cystic pancreatic neoplasms
- pancreas transplant
- gastrointestinal ultrasound
- renal ultrasound
- renal stone
- focal lesion
- renal vascular
- renal transplant ultrasound
- bladder ultrasound
- scrotal/testicular ultrasound
- unilateral testicular lesion
- bilateral testicular lesion
- cyst of the tunica albuginea
- tubular ectasia of the rete testis
- testicular lymphoma
- prostate carcinoma
- other lower genitourinary
- neck and thyroid ultrasound
- pediatric ultrasound
- ultrasound interventions
- ultrasound guided biopsy
- ultrasound guided percutaneous drainage
- ultrasound guided musculoskeletal interventions
- joint injection
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- 2. Atri M, Reinhold C, Mehio AR et-al. Adenomyosis: US features with histologic correlation in an in-vitro study. Radiology. 2000;215 (3): 783-90. Radiology (full text) - Pubmed citation
- 3. Verma SK, Lev-toaff AS, Baltarowich OH et-al. Adenomyosis: sonohysterography with MRI correlation. AJR Am J Roentgenol. 2009;192 (4): 1112-6. doi:10.2214/AJR.08.1405 - Pubmed citation
- 4. Hulse P, Carrington BM. MRI manual of pelvic cancer. Informa HealthCare. (2004) ISBN:1859960693. Read it at Google Books - Find it at Amazon
- 5. Hamm B, Forstner R, Beinder E. MRI and CT of the female pelvis. Springer Verlag. (2007) ISBN:3540222898. Read it at Google Books - Find it at Amazon
- 6. Togashi K, Nishimura K, Itoh K et-al. Adenomyosis: diagnosis with MR imaging. Radiology. 1988;166 (1): 111-4. Radiology (abstract) - Pubmed citation
- 7. Tamai K, Togashi K, Ito T et-al. MR imaging findings of adenomyosis: correlation with histopathologic features and diagnostic pitfalls. Radiographics. 25 (1): 21-40. doi:10.1148/rg.251045060 - Pubmed citation
- 8. Reinhold C, Tafazoli F, Mehio A et-al. Uterine adenomyosis: endovaginal US and MR imaging features with histopathologic correlation. Radiographics. 1999;19 Spec No : S147-60. - Pubmed citation
- 9. Novellas S, Chassang M, Delotte J et-al. MRI characteristics of the uterine junctional zone: from normal to the diagnosis of adenomyosis. AJR Am J Roentgenol. 2011;196 (5): 1206-13. doi:10.2214/AJR.10.4877 - Pubmed citation
- 10. Hulka CA, Hall DA, Mccarthy K et-al. Sonographic findings in patients with adenomyosis: can sonography assist in predicting extent of disease? AJR Am J Roentgenol. 2002;179 (2): 379-83. AJR Am J Roentgenol (full text) - Pubmed citation
- 11. Sakhel K, Abuhamad A. Sonography of adenomyosis. J Ultrasound Med. 2012;31 (5): 805-8. J Ultrasound Med (full text) - Pubmed citation
- 12. Taran FA, Stewart EA, Brucker S. Adenomyosis: Epidemiology, Risk Factors, Clinical Phenotype and Surgical and Interventional Alternatives to Hysterectomy. Geburtshilfe Frauenheilkd. 2013;73 (09): 924-931. doi:10.1055/s-0033-1350840 - Free text at pubmed - Pubmed citation
Synonyms & Alternative Spellings
|Synonyms or Alternative Spelling||Include in Listings?|
|Adenomyosis of the uterus||✗|
|Adenomyosis of uterus||✗|