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Adrenal adenoma

Adrenal adenomas are the commonest adrenal mass lesion, and are often found incidentally during abdominal imaging for other reasons. In all cases, but especially in the setting of known current or previous malignancy, adrenal adenomas need to be distinguished from adrenal metastases or other adrenal malignancies.

Terminology

The term incidental adrenal lesion (also colloquially known as an incidentaloma) is sometimes used interchangeably with adrenal adenoma, although in truth an incidental adrenal lesion includes all pathologies (including malignancies). As such, the term should be avoided lest it results in confusion.

Epidemiology

Adrenal adenomas are found in almost all age groups but increase in frequency with age 4.

Clinical presentation

The majority of adrenal adenomas are non-functioning, in which case they are asymptomatic.

Patients with hyperfunctioning adrenal gland adenomas present with manifestations of excess hormone secretion.  The most common disease states caused by functioning adenomas are Cushing syndrome (due to excess cortisol production), Conn syndrome (due to excess aldosterone production) or sex-hormone related symptoms 4.

Radiographic features

Imaging plays a key role in assessing the vast number of incidental adrenal lesions, the majority of which are adrenal adenomas. Correlation with previous imaging is often useful, as a lesion which has not changed over a number of years is unlikely to be malignant.

General

They can be divided into those that have typical or atypical appearances.

Typical adenomas are:

  • small: < 3 cm
  • homogeneous and low density

Atypical features include:

  • haemorrhage
  • calcification
  • necrosis
  • no fat
  • large: > 3 cm
    • if greater than 4 cm: 70% malignant (excluding adrenal myelolipomas which are easily recognised due to fat, and pheochromocytomas which are usually recognised biochemically)
    • if greater than 6 cm: 85% malignant 4
CT

CT is often the modality which identifies an adrenal mass. Fortunately using density is highly sensitive and specific as 70% of adrenal adenomas contain significant intracellular fat.  Lipid-poor adenomas are more difficult to diagnose because the CT numbers increase and approach those of soft tissue.

For lipid poor lesions, the contrast washout  rate can be determined at CT. Adenomas typically have rapid contrast washout, whereas non-adenomas tend to wash out more slowly. There are different protocols, and some controversy exists as to which protocol is the best. A 5 or 10 minute protocol may be more suitable for busy CT lists. However there is evidence that a 15 minutes post contrast protocol has better diagnostic accuracy11

  • non-contrast imaging 4
    • < 0 HU: considered 47% sensitive and 100% specific
    • < 10 HU: considered 71% sensitive and 98% specific
  • washout imaging
    • 10 minutes post contrast
    • < 30 HU 10min post contrast: considered 80% sensitive and 100% specific
    • > 50% washout c.f. to portal venous phase: considered 98% sensitive and 100% specific (this is the most reliable test to differentiate between benign and malignant adrenal lesions 4)
MRI

Chemical shift imaging is the most reliable for diagnosis especially when CT findings are equivocal. Because of the high sensitivity of chemical shift MR imaging to minute amounts of intravoxel fat, MR imaging demonstrates signal intensity loss on opposed-phase images in the majority of adenomas, and a drop in signal intensity of greater than 20% is considered diagnostic for an adenoma 2. Rather than measuring the signal, one can compare the adenoma in and out of phase, with images windowed similarly (using the spleen or muscle as a reference - NB do not use the liver as it can change signal on in and out of phase imaging depending on presence of heamochromatosis or hepatic steatosis) 4.

As MRIs are usually performed to help indeterminate CT lesions, the sensitivity and specificity depends on the CT density. A drop in signal on out of phase imaging for:

  • 10-30 HU on CT is 89% sensitive and 100% specific
  • 10-20 HU on CT is 100% sensitive and 100% specific

Malignant adrenal lesions also demonstrate restricted diffusion 4.

Treatment and prognosis

Small adrenal mass with manifestations of hormonal excess need resection, as do large (> 3 to 5 cm) non functioning adrenal mass lesions as they are considered potentially malignant (see adrenal carcinoma)

Small adrenal lesions with typical features of adenomas and with out biochemical abnormality can be safely left in situ.

Differential diagnosis

Consider other adrenal lesions such as

See also

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