Adrenal adenomas are the commonest adrenal mass lesion, and are often found incidentally during abdominal imaging for other reasons. In all cases, but especially in the setting of known current or previous malignancy, adrenal adenomas need to be distinguished from adrenal metastases or other adrenal malignancies.
The term incidental adrenal lesion (also colloquially known as an incidentaloma) is sometimes used interchangeably with adrenal adenoma, although in truth an incidental adrenal lesion includes all pathologies (including malignancies). As such, the term should be avoided lest it results in confusion.
Adrenal adenomas are found in almost all age groups but increase in frequency with age 4.
The majority of adrenal adenomas are non-functioning, in which case they are asymptomatic.
Patients with hyperfunctioning adrenal gland adenomas present with manifestations of excess hormone secretion. The most common disease states caused by functioning adenomas are Cushing syndrome (due to excess cortisol production), Conn syndrome (due to excess aldosterone production) or sex-hormone related symptoms 4.
Imaging plays a key role in assessing the vast number of incidental adrenal lesions, the majority of which are adrenal adenomas. Correlation with previous imaging is often useful, as a lesion which has not changed over a number of years is unlikely to be malignant.
They can be divided into those that have typical or atypical appearances.
Typical adenomas are:
- small: < 3 cm
- homogeneous and low density
Atypical features include:
- no fat
- large: > 3 cm
CT is often the modality which identifies an adrenal mass. Fortunately using density is highly sensitive and specific as 70% of adrenal adenomas contain significant intracellular fat. Lipid-poor adenomas are more difficult to diagnose because the CT numbers increase and approach those of soft tissue.
For lipid poor lesions, the contrast washout rate can be calculated at CT. Adenomas typically have rapid contrast washout, whereas non-adenomas tend to wash out more slowly. There are different protocols, and some controversy exists as to which protocol is the best. A 5 or 10 minute protocol may be more suitable for busy CT lists. However there is evidence that a 15 minutes post contrast protocol has better diagnostic accuracy.11
- non-contrast imaging 4
- < 0 HU: considered 47% sensitive and 100% specific
- < 10 HU: considered 71% sensitive and 98% specific
- washout imaging
It is important to note that hypervascular metastases may show identical washout values, particularly those from renal cell carcinoma and hepatocellular carcinoma. An alternative diagnosis to adrenal adenoma must be considered when there is a value over 120 HU on the portal venous phase, particularly in cases with prior history of neoplasm12.
Chemical shift imaging is the most reliable for diagnosis especially when CT findings are equivocal. Because of the high sensitivity of chemical shift MR imaging to minute amounts of intravoxel fat, MR imaging demonstrates signal intensity loss on opposed-phase images in the majority of adenomas, and a drop in signal intensity of greater than 20% is considered diagnostic for an adenoma 2. Rather than measuring the signal, one can compare the adenoma in and out of phase, with images windowed similarly (using the spleen or muscle as a reference - NB do not use the liver as it can change signal on in and out of phase imaging depending on presence of heamochromatosis or hepatic steatosis) 4.
As MRIs are usually performed to help indeterminate CT lesions, the sensitivity and specificity depends on the CT density. MRI is useful in adrenal mass with an attenuation < 30 HU. A drop in signal on out of phase imaging for:
- 10-30 HU on CT is 89% sensitive and 100% specific
- 10-20 HU on CT is 100% sensitive and 100% specific
Malignant adrenal lesions also demonstrate restricted diffusion 4.
Treatment and prognosis
Small adrenal mass with manifestations of hormonal excess need resection, as do large (> 3 to 5 cm) non functioning adrenal mass lesions as they are considered potentially malignant (see adrenal carcinoma)
Small adrenal lesions with typical features of adenomas and with out biochemical abnormality can be safely left in situ.
Consider other adrenal lesions such as
- adrenocortical carcinoma
- adrenal metastasis
- focal adrenal granulomatous disease
- adrenal myelolipoma
- 1. Pereira JM, Sirlin CB, Pinto PS et-al. CT and MR imaging of extrahepatic fatty masses of the abdomen and pelvis: techniques, diagnosis, differential diagnosis, and pitfalls. Radiographics. 25 (1): 69-85. doi:10.1148/rg.251045074 - Pubmed citation
- 2. Elsayes KM, Mukundan G, Narra VR et-al. Adrenal masses: mr imaging features with pathologic correlation. Radiographics. 2004;24 Suppl 1 (suppl 1): S73-86. doi:10.1148/rg.24si045514 - Pubmed citation
- 3. Rockall AG, Babar SA, Sohaib SA et-al. CT and MR imaging of the adrenal glands in ACTH-independent cushing syndrome. Radiographics. 24 (2): 435-52. doi:10.1148/rg.242035092 - Pubmed citation
- 4. Blake MA, Holalkere NS, Boland GW. Imaging techniques for adrenal lesion characterization. Radiol. Clin. North Am. 2008;46 (1): 65-78, vi. doi:10.1016/j.rcl.2008.01.003 - Pubmed citation
- 5. Korobkin M. CT characterization of adrenal masses: the time has come. Radiology. 2000;217 (3): 629-32. Radiology (full text) - Pubmed citation
- 6. Korobkin M, Brodeur FJ, Yutzy GG et-al. Differentiation of adrenal adenomas from nonadenomas using CT attenuation values. AJR Am J Roentgenol. 1996;166 (3): 531-6. AJR Am J Roentgenol (abstract) - Pubmed citation
- 7. Peña CS, Boland GW, Hahn PF et-al. Characterization of indeterminate (lipid-poor) adrenal masses: use of washout characteristics at contrast-enhanced CT. Radiology. 2000;217 (3): 798-802. Radiology (full text) - Pubmed citation
- 8. Blake MA, Cronin CG, Boland GW. Adrenal imaging. AJR Am J Roentgenol. 2010;194 (6): 1450-60. doi:10.2214/AJR.10.4547 - Pubmed citation
- 9. Boland GW, Blake MA, Hahn PF et-al. Incidental adrenal lesions: principles, techniques, and algorithms for imaging characterization. Radiology. 2008;249 (3): 756-75. doi:10.1148/radiol.2493070976 - Pubmed citation
- 10. Caoili EM, Korobkin M, Francis IR et-al. Delayed enhanced CT of lipid-poor adrenal adenomas. AJR Am J Roentgenol. 2000;175 (5): 1411-5. AJR Am J Roentgenol (full text) - Pubmed citation
- 11. Sangwaiya MJ, Boland GW, Cronin CG et-al. Incidental adrenal lesions: accuracy of characterization with contrast-enhanced washout multidetector CT-10-minute delayed imaging protocol revisited in a large patient cohort. Radiology. 2010;256 (2): 504-10. doi:10.1148/radiol.10091386 - Pubmed citation
- 12. Choi YA, Kim CK, Park BK et-al. Evaluation of adrenal metastases from renal cell carcinoma and hepatocellular carcinoma: use of delayed contrast-enhanced CT. Radiology. 2013;266 (2): 514-20. Radiology (full text) - doi:10.1148/radiol.12120110 - Pubmed citation
Synonyms & Alternative Spellings
|Synonyms or Alternative Spelling||Include in Listings?|