Adrenal hyperplasia

Dr Owen Kang and Dr Yuranga Weerakkody et al.

Adrenal hyperplasia refers to nonmalignant growth (enlargement) of the adrenal glands and is a rare cause of ACTH independent Cushing syndrome with unilateral adrenal cortical adenomas being the commonest. 20% of Conn syndrome cases are secondary to adrenal hyperplasia.  In diffuse hyperplasia, the limbs of the adrenal glands are >5 cm in length and >10 mm in thickness. 

Pathology

Classification

Adrenal hyperplasia can be classified according to:

Radiographic features

  • enlarged limbs of one or both adrenal glands >10 mm
  • normal adrenal morphology maintained
  • nodular or uniform
MRI
  • high lipid content and thus may demonstrate signal drop out in out-of-phase imaging
  • signal drop out due to lipid content overlaps with adrenal cortical adenomas

See also

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