Adrenal myelolipomas are rare benign tumours of the adrenal gland with an estimated autopsy prevalence of 0.1-0.2%.
These tumours are usually identified in adults, either incidentally or if complicated by haemorrhage (see below). There is no gender predilection 9.
Most lesions are asymptomatic 6 and may be discovered incidentally when the region is imaged for other reasons (i.e. an incidentaloma). Larger lesions (typically over 4 cm in size) can present with with an acute retroperitoneal haemorrhage, and still others (especially when very large) with vague mass related symptoms 9. There may be a right sided predilection 5.
Although the tumour itself is non-functioning there is a relatively high incidence (10%) of associated endocrine disorders 9:
- Cushing syndrome
- congenital adrenal hyperplasia (21-hydroxylase deficiency)
- Conn syndrome (hypenaldostenonism)
Histological examination demonstrates variable amounts of:
- mature adipocytes (with distended lipid vacuoles) similar to bone marrow
- hematopoietic cells (including cells from myeloid, erythroid and megakaryocytic cells lines)
The fatty component is often the predominant feature and therefore the most characteristic feature on imaging. The lesions can infrequently contain bone 10 or show partial replacement by haemorrhage or fibrosis.
Exact sonographic appearances are varied depending on individual tumour components 1. Usually be seen as a heterogenous mass of mixed hyper- and hypoechoic components with the former primarily resulting from fatty portions.
The CT appearance is usually characteristic. The typical adrenal myelolipoma appears as an adrenal mass with fat-containing components. The mass is usually relatively well circumscribed, however masses that are mostly fat may be difficult to separate from surrounding retroperitoneal fat.
The amount of fatty component is variable, ranging from only a few small regions in an otherwise mostly soft tissue density mass (10%) to masses made up of roughly equal components of fat and soft tissue (50%) or almost completely composed of fatty tissue (40%) 9. The soft tissue and fatty components can be sufficiently mixed in some cases to render the mass a density similar to fluid.
Small punctate calcifications may be seen in 25-30% of cases 4,9.
If haemorrhage is present then regions of higher attenuation may be seen. This is more frequently seen in large lesions (>10 cm) 3.
- T1: typically hyperintense due to fat contents
- T1 (FS): typically shows fat suppression
- T2: generally intermediate to hyperintense but can sometimes vary depending on contents (especially blood products)
- T1 C+ (Gd): shows striking enhancement 1
- in and out of phase: in masses with mixed components, out of phase imaging may demonstrate signal loss as the macroscopic fat cells usually have little intracellular water 9,11
Adrenal myelolipomas typically do not demonstrate an avid FDG uptake. It is generally lower than that of the liver background. However, in rare cases the adenomatous and hematopoietic elements can show an increased FDG uptake 12,13.
Treatment and prognosis
They are benign lesions histologically and there is currently no recognised malignant potential 5. As such, if imaging features are characteristic and the lesion is small, no treatment is required.
If imaging findings are indeterminate, percutaneous biopsy can be performed. In larger lesions or where haemorrhage has occurred surgical excision is curative.
General imaging differential considerations include:
- retroperitoneal liposarcoma
- fat containing adrenocortical carcinoma
- adrenal teratoma: extremely rare
- renal angiomyolipoma (AML)
History and etymology
Initially described by Gierke 6 in 1905 with the term myelolipoma coined by Obenling in 1929 7.
- 1. Cyran KM, Kenney PJ, Memel DS et-al. Adrenal myelolipoma. AJR Am J Roentgenol. 1996;166 (2): 395-400. AJR Am J Roentgenol (abstract) - Pubmed citation
- 2. Bhansali A, Kotwal N, Ganpathi B. Adrenal myelolipoma. Postgrad Med J. 2001;77 (910): 513. doi:10.1136/pmj.77.910.513 - Free text at pubmed - Pubmed citation
- 3. Routhier JR, Woodfield CA, Mayo-smith WW. AJR teaching file: fat-containing retroperitoneal mass presenting with acute flank pain. AJR Am J Roentgenol. 2009;192 (6): S122-4. doi:10.2214/AJR.07.7007 - Pubmed citation
- 4. Craig WD, Fanburg-smith JC, Henry LR et-al. Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. Radiographics. 29 (1): 261-90. doi:10.1148/rg.291085203 - Pubmed citation
- 5. Kenney PJ, Wagner BJ, Rao P et-al. Myelolipoma: CT and pathologic features. Radiology. 1998;208 (1): 87-95. Radiology (abstract) - Pubmed citation
- 6. Gierke E. Uber knochenmarksgewebe in den nebenniene. Beitn Path Anat 1905; 7:311-325.
- 7. Oberling C. Les formations myelolipomatouses. Bull Cancer 1929; 18:234-246.
- 8. Palmer WE, Gerard-mcfarland EL, Chew FS. Adrenal myelolipoma. AJR Am J Roentgenol. 1991;156 (4): 724. AJR Am J Roentgenol (citation) - Pubmed citation
- 9. Lee JK. Computed body tomography with MRI correlation. Lippincott Williams & Wilkins. (2006) ISBN:0781745268. Read it at Google Books - Find it at Amazon
- 10. Rossi A, Incensati R. Bone tissue in adrenal myelolipoma: a case report. Tumori. 84 (1): 90-3. - Pubmed citation
- 11. Brant WE, Helms CA. Fundamentals of Diagnostic Radiology. Lippincott Williams & Wilkins. (2007) ISBN:0781761352. Read it at Google Books - Find it at Amazon
- 12. Dong A, Cui Y, Wang Y et-al. (18)F-FDG PET/CT of adrenal lesions. AJR Am J Roentgenol. 2014;203 (2): 245-52. doi:10.2214/AJR.13.11793 - Pubmed citation
- 13. Elaini AB, Shetty SK, Chapman VM et-al. Improved detection and characterization of adrenal disease with PET-CT. Radiographics. 2007;27 (3): 755-67. doi:10.1148/rg.273055031 - Pubmed citation
Synonyms & Alternative Spellings
|Synonyms or Alternative Spelling||Include in Listings?|
|Myelolipoma of adrenal gland||✗|
|Myelolipoma of adrenal glands||✗|