Approximately two thirds of this sub type are discovered in post-menopausal age.
As they often produce oestrogen and may present with abnormal vaginal bleeding.
Macroscopically, typical adult ovarian granulosa cell tumours form large multi-septated cystic masses or solid masses with variable amounts of cystic components. These cystic components often contain haemorrhage.
Microscopically, the tumour cells with pale nuclei that frequently have regular follicles without mucin, longitudinal grooves grow in sheets, trabecular patterns, or strands with gland like structures filled with an acidophilic material recalling immature follicles (Call-Exner bodies).
- there can be accompanying endometrial hyperplasia due to oestrogen secretion
- 1. Eurorad teaching files : Case 6674
- 2. Pectasides D, Papaxoinis G, Fountzilas G et-al. Adult granulosa cell tumors of the ovary: a clinicopathological study of 34 patients by the Hellenic Cooperative Oncology Group (HeCOG). Anticancer Res. 28 (2B): 1421-7. Anticancer Res. (link) - Pubmed citation
- 3. Schumer ST, Cannistra SA. Granulosa cell tumor of the ovary. J. Clin. Oncol. 2003;21 (6): 1180-9. doi:10.1200/JCO.2003.10.019 - Pubmed citation
Synonyms & Alternative Spellings
|Synonyms or Alternative Spelling||Include in Listings?|
|Adult granulosa cell tumour of ovary||✗|
|Adult ovarian granulosa||✗|
|Adult granulosa cell tumours of the ovary||✗|
|Adult granulosa cell tumors of the ovary||✗|