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Adult granulosa cell tumour of the ovary

Dr Praveen Jha and Radswiki et al.

Adult granulosa cell tumours of the ovary are by far more frequent sub type of granulosa cell tumours of the ovary. It is a type of ovarian sex cord -stromal tumour.

Epidemiology

Approximately two thirds of this sub type are discovered in post-menopausal age.

Clinical presentation

As they often produce oestrogen and may present with abnormal vaginal bleeding.

Pathology

Macroscopically, typical adult ovarian granulosa cell tumours form large multi-septated cystic masses or solid masses with variable amounts of cystic components. These cystic components often contain haemorrhage.
Microscopically, the tumour cells with pale nuclei that frequently have regular follicles without mucin, longitudinal grooves grow in sheets, trabecular patterns, or strands with gland like structures filled with an acidophilic material recalling immature follicles (Call-Exner bodies).

Associations

See also

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