An asbestos body is a histological finding in interstitial lung disease that is suggestive of significant occupational asbestos exposure. They are usually identified following a parenchymal lung biopsy 3.
Macrophage ingestion of the asbestos fibres triggers a fibrogenic response via the release of growth factors that promote collagen deposition by fibroblasts. The fibres become encased in iron-rich material derived from proteins such as ferritin and haemosiderin 5. They typically appear as brown nodules in the septum of the alveolus and may have a rod or dumbbell shape with multiple segmentations.
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- 3. Chong S, Lee KS, Chung MJ et-al. Pneumoconiosis: comparison of imaging and pathologic findings. Radiographics. 26 (1): 59-77. doi:10.1148/rg.261055070 - Pubmed citation
- 4. Friedman AC, Fiel SB, Fisher MS et-al. Asbestos-related pleural disease and asbestosis: a comparison of CT and chest radiography. AJR Am J Roentgenol. 1988;150 (2): 269-75. AJR Am J Roentgenol (abstract) - Pubmed citation
- 5. Churg AM, Warnock ML. Asbestos and other ferruginous bodies: their formation and clinical significance. Am. J. Pathol. 1981;102 (3): 447-56. - Free text at pubmed - Pubmed citation
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