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Atypical ductal hyperplasia

Dr Yuranga Weerakkody and Radswiki et al.

Atypical ductal hyperplasia (ADH) is a histologically borderline lesion that has some, but not all the features of ductal carcinoma in situ (DCIS). Sometimes the distinction between ADH and DCIS is simply on the basis of the number of ducts involved 5. 

Pathology

Atypical ductal hyperplasia lacks the strict criteria for ductal carcinoma in situ. Involvement of a single duct or an aggregate diameter of involvement of less that 2 mm constitutes a diagnosis of atypical ductal hyperplasia, and a more extensive lesion with the same histologic features is labeled ductal carcinoma in situ.

Treatment and prognosis

ADH is considered a high risk breast lesion. Therefore surgical excision is advised as under-estimation of ductal carcinoma in situ encountered when atypical ductal hyperplasia is retrieved on a large core needle biopsy (up to a 3rd of cases may be upstaged to DCIS).

See also

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