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Bethesda criteria of HNPCC

The Bethesda criteria are an alternative to the Amsterdam criteria for the clinical diagnosis of HNPCC

Diagnosis of  HNPCC is made if any of the following criteria are fulfilled:

  • Amsterdam criteria are met
  • 2 or more HNPCC related malignancies 
  • patient with colorectal cancer (CRC) has
  • first degree relative with CRC or HNPCC related cancer; one of the cancers diagnosed <45 years of age, and the adenoma diagnosed <40 year of age
  • CRC and endometrial cancer < 45 years of age
  • right sided undifferentiated (solid or cribiform) CRC on histology diagnosed <45 years of age
  • signet ring type CRC <45 years of age
  • colonic adenomas <40 years of age

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