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Clinically isolated syndrome

Dr Frank Gaillard et al.

Clinically isolated syndrome (CIS) is the first episode suggestive of demyelination. It can either be monofocal (single lesion) or multifocal. Not all patients with CIS will go on to develop multiple sclerosis (MS) however if at presentation there are changes on MRI suggestive of MS, then the chances of progressing to MS are high.

For the diagnosis of MS, there needs to be both dissemination in time and space. (see McDonald Diagnostic Criteria for MS)