Cobblestoning (having a cobblestone appearance) can occur in a number of hollow organs with mucosa, most commonly the bowel, in the setting of Crohn's disease

Longitudinal and circumferential fissures and ulcers separate islands of mucosa, giving it an appearance reminiscent of cobblestones. 

Cobblestone appearance has been reported in:

Other disease processes can present with a cobblestone-like imaging characteristics.

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