Echogenic intracardiac focus

Echogenic intracardiac focus (EIF) is a relatively common sonographic observation that may be present on an antenatal ultrasound scan.


They are thought to be present in ~4-5% of karyotypically normal fetuses. They may be commoner in the Asian population 5


They are considered to represent mineralisation within papillary muscle.


The majority of echogenic intracardiac foci are unilateral. Out of all the cardiac chambers, the left ventricle is the most frequent in terms of location.


The tightness of the association between an isolated EIF and aneuploidy continues to be debated. Biventricular EIFs are considered to be higher risk for aneuploidy, however.

Radiographic features

Antenatal ultrasound

They are typically seen as a small bright echoic focus within the fetal heart on a four chamber view (often as bright as bone).

Tissue harmonic imaging should be turned off when evaluating a potential EIF, to avoid false positives. If it is difficult to tell if the EIF is as bright as bone, the gain in the image can be decreased to see which structure disappears first.

Treatment and prognosis

  • the presence of an echogenic intracardiac focus has to be interpreted in the context of maternal risk factors and other sonographic anomalies
  • when seen in isolation in a normal pregnancy it is considered a benign variant 
  • in high risk pregnancies, there is an increased incidence of aneuploidic anomalies (e.g. Down syndrome 2-3 and trisomy 13 3)
    • classified as soft marker for aneuploidic anomalies
    • the presence of multiple or bilateral (more than one chamber) echogenic foci may increase the risk
  • there is no recognised direct association with congenital heart disease for a EIF on its own 1 (unless there is an associated aneuploidic anomaly) 

They usually disappear during the 3rd trimester 7.

Related articles

Ultrasound - obstetric

Updating… Please wait.


Error Unable to process the form. Check for errors and try again.

Alert_accept Thank you for updating your details.