Enchondromas (or chondromas 7) are a relatively common benign medullary cartilaginous neoplasm with benign imaging features. They account of the E in the popular mnemonic for bubbly bone lesions FEGNOMASHIC. They are sometimes classified under the umbrella term low grade chondral series tumours.


Enchondromas are most frequently diagnosed in childhood to early adulthood with a peak incidence of 10-30 years. They account for ~5% (range 3-10%) of all bone tumours and ~17.5% (range 12-24%) of benign bone tumours 1.

Clinical presentation

Mostly there are an incidental finding. They are usually asymptomatic, but may be complicated by a pathological fracture or malignant transformation into a low-grade chondrosarcoma. The latter is rare.

It is important to note that if an enchondroma is painful in the absence of a fracture, it should be considered malignant.


Enchondromas arise from rests of growth plate cartilage/chondrocytes that subsequently proliferate and slowly enlarge and are composed of mature hyaline cartilage. Hence, they are seen in any bone formed from cartilage. Lesions are usually <3 cm, translucent, nodular, and are grossly grey-blue.


Two syndromes are associated with multiple enchondromas:


Almost all enchondromas are located centrally within the medullary cavity of tubular bones. The typical distribution is:

  • small tubular bones of the hands and feet: 50% 4
  • large tubular bones, e.g. femur, tibia, humerus

Rarely an enchondroma may extend through the cortex and demonstrate an exophytic growth pattern. This is known as an enchondroma protuberans, and may either be seen sporadically or as part of Ollier disease 2.

Radiographic features

Radiograph and CT

When located in the phalanges enchondroma is expansile and purely lytic. In other locations, enchondromas are expansile, with characteristic calcifications “rings and arcs”. Typically enchondromas are small 1-2 cm lytic lesions with non-aggressive features:

  • narrow zone of transition
  • sharply defined scalloped margins: may have mild endosteal scalloping
  • expansion of the overlying cortex may be present but there should not be cortical breakthrough unless fractured
  • chondroid calcifications may be present: rings and arcs calcification
  • no periosteal reaction
  • no soft tissue mass

The majority of enchondromas more frequently arise in the metaphyseal region, owing presumably to their origin from the growth plate 1, although they are frequently seen in the diaphysis. They only rarely are seen in the epiphysis, and a cartilaginous lesion in an epiphysis is more likely to be a chondrosarcoma 3.


MRI is useful in evaluating for soft tissue extension and for confirming the diagnosis. Enchondromas appear as well circumscribed somewhat lobulated masses replacing marrow 1.

  • T1: intermediate to low-signal
  • T1 C+ (Gd)
    • enhancement is variable, and may be seen both peripherally or of translesional septae
    • similar pattern of enhancement may be seen in chondrosarcomas 3,6
  • T2
    • typically of background intense high signal
    • they can be focal regions of signal drop out where calcification present
    • no bone marrow or soft tissue oedema

Differentiation of an enchondroma from a low-grade chondrosarcoma is problematic, as they can have very similar appearances. See enchondroma vs. low-grade chondrosarcoma.

Nuclear medicine

Increased uptake on the bone scan can be seen with enchondromas. Intense uptake occurs with underlying pathological fracture or cortical expansion in small bones 5.


  • pathological fractures
  • malignant transformation into: chondrosarcomas

Treatment and prognosis

The majority of enchondromas remain asymptomatic and require no treatment. In the setting of a fracture, the bone may be allowed to heal. If necessary, a curettage and bone grafting can be performed at a later time. 

If malignant transformation is suspected, which occurs in less than 5% of cases, then treatment is more aggressive 4. See also: chondrosarcoma.

Differential diagnosis

The differential is significantly affected by the modality in question, and most entities below can be excluded with MRI. The exception is chondrosarcoma.

Bone tumours

The differential diagnosis for bone tumours is dependent on the age of the patient, with a very different set of differentials for the paediatric patient.

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