The incidence is highly variable dependent on individual countries.
The majority of infants (~75%) are asymptomatic.
Fetal transmission occurs in ~ 40% of cases where primary maternal infection is acquired during pregnancy 3. Transmission of infection acquired prior to conception is uncommon and in most cases infection is transmitted in the 3rd trimester. In ~ 10% cases the infection tends to be severe.
It classically gives a triad of (affected in ~ 80% 3)
- PCR test on amniotic fluid : more specific 7
- cordocentesis for the detection of T. gondii-specific IgM antibodies : usually detectable after 20 weeks of gestation
Intracranial findings that may be present sonographically include:
- fetal hydrocephalus
- fetal intracranial calcification : tends to be distributed randomly throughout the brain
There may also be presence of microcephaly.
Other findings include
- development of fetal hydrops
Treatment and prognosis
Treatment involves maternal therapy with medications such as spiramycin + / - sulfadiazine + / - pyrimethamine depending on gestational age and the infective status of the fetus. Prognosis is variable dependant on fetal CNS manifestations. Long term disability can occur with mental retardation and blindness. Overall mortality can be as high as 12% 10.
- 1. Hohlfeld P, Daffos F, Thulliez P et-al. Fetal toxoplasmosis: outcome of pregnancy and infant follow-up after in utero treatment. J. Pediatr. 1989;115 (5 Pt 1): 765-9. - Pubmed citation
- 2. Bessières MH, Berrebi A, Rolland M et-al. Neonatal screening for congenital toxoplasmosis in a cohort of 165 women infected during pregnancy and influence of in utero treatment on the results of neonatal tests. Eur. J. Obstet. Gynecol. Reprod. Biol. 2001;94 (1): 37-45. Eur. J. Obstet. Gynecol. Reprod. Biol. (link) - Pubmed citation
- 3. Entezami M, Albig M, Knoll U et-al. Ultrasound Diagnosis of Fetal Anomalies. Thieme. (2003) ISBN:1588902129. Read it at Google Books - Find it at Amazon
- 4. Winn HN, Hobbins JC. Clinical maternal-fetal medicine. Taylor & Francis. (2000) ISBN:1850707987. Read it at Google Books - Find it at Amazon
- 5. Levene MI, Chervenak FA. Fetal and Neonatal Neurology and Neurosurgery. Churchill Livingstone. (2009) ISBN:0443104077. Read it at Google Books - Find it at Amazon
- 6. Gay-andrieu F, Marty P, Pialat J et-al. Fetal toxoplasmosis and negative amniocentesis: necessity of an ultrasound follow-up. Prenat. Diagn. 2003;23 (7): 558-60. doi:10.1002/pd.632 - Pubmed citation
- 7. Foulon W, Pinon JM, Stray-pedersen B et-al. Prenatal diagnosis of congenital toxoplasmosis: a multicenter evaluation of different diagnostic parameters. Am. J. Obstet. Gynecol. 1999;181 (4): 843-7. - Pubmed citation
- 8. Antsaklis A, Daskalakis G, Papantoniou N et-al. Prenatal diagnosis of congenital toxoplasmosis. Prenat. Diagn. 2002;22 (12): 1107-11. doi:10.1002/pd.476 - Pubmed citation
- 9. Foulon W, Naessens A, Ho-yen D. Prevention of congenital toxoplasmosis. J Perinat Med. 2000;28 (5): 337-45. doi:10.1515/JPM.2000.043 - Pubmed citation
- 10. Entezami M, Albig M, Knoll U et-al. Ultrasound Diagnosis of Fetal Anomalies. Thieme. (2003) ISBN:1588902129. Read it at Google Books - Find it at Amazon
Synonyms & Alternative Spellings
|Synonyms or Alternative Spelling||Include in Listings?|
|In utero toxoplasmosis infection||✗|
|Congenital toxoplasmosis infection||✗|
|Fetal toxoplasma infection||✗|