Gastrinomas are the second most common pancreatic endocrine tumour and the most common type in the setting of multiple endocrine neoplasia type I (MEN I).
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Most gastrinomas are sporadic, although some are seen in the setting of multiple endocrine neoplasia type I (MEN I). In general, these present in young adults 1.
Gastrinomas occur in ~0.1% of patients with peptic ulcer disease.
Due to the physiological action of gastrin (>1000 pg/ml), resulting in excessive secretion of acid into the stomach, initial manifestations is with peptic ulcer disease (PUD) with multiple recurrent and intractable ulcers, often in unusual locations. This constellation of findings due to a gastrinoma is known as Zollinger-Ellison syndrome.
Diarrhoea due to the large volume of hydrochloric acid and a direct effect of gastrin on the small bowel is also common.
Gastrinomas are usually malignant and as they are frequently multiple and often extrapancreatic (90% located in the gastrinoma triangle). They are more commonly located in the duodenum than in the pancreas.
Tumour size is variable
- duodenal gastrinomas are usually <1 cm
- pancreatic gastrinomas average 3-4 cm
Gastrinomas can be difficult to locate, as such multiphase contrast enhanced thin slice cross-sectional imaging is ideal. The lesions are often hypervascular, so they may be visible on arterial phase CT and angiography.
Because gastrinomas often have abundant somatostatin receptors, In-111 octreotide studies have a higher sensitivity for these pancreatic endocrine tumours.
Treatment and prognosis
Hepatic metastases are associated with a poor prognosis, whereas patients with metastases isolated to lymph nodes often have long-term survival.
- cystic neoplasm (cystic pancreatic mass differential diagnosis)
- solid neoplasm
- nonepithelial pancreatic neoplasms
- gallstone pancreatitis
- interstitial oedematous pancreatitis
- necrotising pancreatitis
- haemorrhagic pancreatitis
- revised Atlanta classification of acute pancreatitis
- chronic pancreatitis
- Ascaris-induced pancreatitis
- tropical pancreatitis
- autoimmune pancreatitis
- emphysematous pancreatitis
- hereditary pancreatitis
- pancreatitis associated with cystic fibrosis
- segmental pancreatitis
- acute pancreatitis
- pancreatic atrophy
- pancreatic lipomatosis
- pancreatic trauma
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- 2. Yu J, Fulcher AS, Turner MA et-al. Normal anatomy and disease processes of the pancreatoduodenal groove: imaging features. AJR Am J Roentgenol. 2004;183 (3): 839-46. AJR Am J Roentgenol (citation) - Pubmed citation
- 3. Lewis RB, Lattin GE, Paal E. Pancreatic endocrine tumors: radiologic-clinicopathologic correlation. Radiographics. 2010;30 (6): 1445-64. doi:10.1148/rg.306105523 - Pubmed citation