The causes of generalized increase in bone density in adult patients can be divided according to broad categories :
- myeloproliferative disorders : myelosclerosis :
- marrow cavity is narrowed by endosteal new bone
- patchy lucencies due to persistence of fibrous tissue (generalized osteopaenia in the early stages due to myelofibrosis.
- with periosteal reaction, prominent muscle attachments and calcification of ligaments and interosseous membranes.
- changes are most marked in the innominate bones and lumbar spine.
- fluorosis :
- neoplastic (more commonly multifocal than generalized)
- osteoblastic metastases : most commonly prostate and breasts.
- sclerosis of marrow containing skeleton with patchy areas of radiolucency
- urticaria pigmentosa
- can have symptoms and signs of carcinoid syndrome.
- idiopathic (more commonly multifocal than generalized)
- Paget's disease : coarsened trabeculae, bony expansion and thickened cortex.
Synonyms & Alternative Spellings
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|Differential diagnosis of generalized increased bone density in adults||✗|