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Gleason score

The Gleason score determines the histological grading of prostate cancer. A score of 1 to 5 is assigned to each of the two largest areas of tumour involvement in the samples obtained, based on the worst feature.

  • 1 = least aggressive
  • 5 = most aggressive

These two scores are then added together to a Gleason score of 2 - 10. This final score can then be grouped variably into histopathologic grades which correlate with progression free survival, although exactly how these are grouped varies from publication-to-publication. For example 1

  • 2 - 4 (low grade):
    • 100% progression free at 5 years 
    • 95.6% progression free at 10 years 
  • 5 - 6:
    • 96.9% progression free at 5 years 
    • 81.9% progression free at 10 years 
  • 7:
    • 76.9% progression free at 5 years 
    • 51.4% progression free at 10 years 
  • 8 - 9:
    • 59.1% progression free at 5 years 
    • 34.9% progression free at 10 years 

History and etymology

Named after Donald Gleason, American (US) pathologist (1920-2008).

See also

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