The Gleason score determines the histological grading of prostate cancer. A score of 1 to 5 is assigned to each of the two largest areas of tumour involvement in the samples obtained, based on the worst feature.
- 1 = least aggressive.
- 5 = most aggressive.
These two scores are then added together to a Gleason score of 2 - 10. This final score can then be grouped variably into histopathologic grades which correlate with progression free survival, although exactly how these are grouped varies from publication to publication. For examples 1:
- 2 - 4 (low grade)
- 100% progression free at 5 years
- 95.6% progression free at 10 years
- 5 - 6
- 96.9% progression free at 5 years
- 81.9% progression free at 10 years
- 76.9% progression free at 5 years
- 51.4% progression free at 10 years
- 8 - 9
- 59.1% progression free at 5 years
- 34.9% progression free at 10 years
Named after Donald Gleason : American (US) pathologist (1920 - 2008)
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