This site is targeted at medical and radiology professionals, contains user contributed content, and material that may be confusing to a lay audience. Use of this site implies acceptance of our Terms of Use.

Gleason score

The Gleason score determines the histological grading of prostate cancer. A score of 1 to 5 is assigned to each of the two largest areas of tumour involvement in the samples obtained, based on the worst feature.

  • 1 = least aggressive.
  • 5 = most aggressive.

These two scores are then added together to a Gleason score of 2 - 10. This final score can then be grouped variably into histopathologic grades which correlate with progression free survival, although exactly how these are grouped varies from publication to publication. For examples 1

  • 2 - 4 (low grade)
    • 100% progression free at 5 years 
    • 95.6% progression free at 10 years 
  • 5 - 6
    • 96.9% progression free at 5 years 
    • 81.9% progression free at 10 years 
  • 7
    • 76.9% progression free at 5 years 
    • 51.4% progression free at 10 years 
  • 8 - 9
    • 59.1% progression free at 5 years 
    • 34.9% progression free at 10 years 

Etymology

Named after Donald Gleason : American (US) pathologist (1920 - 2008)

See also

Updating… Please wait.
Loadinganimation

 Details successfully updated.

Error Unable to process the form. Check for errors and try again.

 Thank you for updating your details.