The Hennebert sign describes a positive fistula test without clinical evidence of middle ear or mastoid disease. It is associated with congenital syphilis and may also be present in Meniere disease.

It has been postulated that the vestibular stimulation is mediated by fibrous bands between footplate of stapes and the vestibular membranous labyrinth. Another explanation is that the vestibular response is due to an excessively mobile footplate.

Nystagmus associated with Hennebert sign usually more marked when negative pressure is applied.

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