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Honeycombing refers to the computed tomographic (CT) manifestation of diffuse pulmonary fibrosis (usual interstitial pneumonia). CT demonstrates clustered cystic air spaces (between 0.3-1.0 cm in diameter), which are usually subpleural and basal in distribution. The walls of the cysts are well-defined and often thick (1-3 mm 4). Honeycombing is an irreversible finding in interstitial lung disease and associated with a poor prognosis.


Honeycombing consists of enlarged airspaces with thick fibrotic wall lined by bronchiolar epithelium and often filled with mucin and inflammatory cells 6.

Differential diagnosis


The term “honeycomb lung” is thought to have originated in the 19th century in Germany and is thought to have  first appeared in 1949 in a study by N Oswald and T Parkinson 5.

See also

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