Hyaline degeneration of a leiomyoma

Hyaline degeneration is the most common form of degeneration that can occur in a uterine leiomyoma


It is thought to occur in up to 60% of uterine leiomyomas 3.


As with many other types of degeneration, it happens when fibroids outgrow their blood supply 4. Hyaline degeneration involves the presence of homogeneous eosinophilic bands or plaques in the extracellular space, which represent accumulation of proteinaceous tissue 1.

Radiographic features

Pelvic MRI 

Typical signal characteristics of a leiomyoma with hyaline or calcific degeneration are difficult to distinguish from non-degenerated fibroids on MRI . Areas of calcification can appear as signal voids on MRI 2.

Therefore typical characteristics include 2-3

  • T2: low signal
  • T1 C+ (Gd): no enhancement

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