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Kasabach-Merritt syndrome

Kasabach-Merritt syndrome (also known as haemangioma thrombocytopaenia syndrome) is a rare life-threatening disease found in infant in which a rapidly growing vascular tumor is responsible for thrombocytopaenia, microangiopathic haemolytic anemia and consumptive coagulopathy.


Kasabach-Merrit syndrome is usually caused by kaposiform haemangioendothelioma or tufted angioma. Other vascular tumors may be responsible, such as infantile haemangioma.


Vascular tumors may grow very rapidly, which can induce severe thrombocytopenia and severe consumptive coagulopathy. In severe case, there may be disseminated intravascular coagulation.

Radiographic features

The radiographic features are specific to each vascular tumor. They can be found in multiple locations, more frequently subcutaneous, musculoskeletal, splenic and hepatic in location.


Various treatments are used, with varying degrees of success, in Kasabach-Merritt syndrome - systemic corticosteroids, radiation therapy, compression, embolisation and/or pharmacotherapy (e.g. interferon, platelet aggregation inhibitors) 4.


Repetitive haemarthrosis can also occur, leading to a haemophilia-like arthropathy 1. Other complications include congestive heart failure and gastrointestinal bleeding 3.

History and etymology

The syndrome is named after Haig Haigouni Kasabach and Katharine Krom Merritt, the two pediatricians who first described the condition in 1940.

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