Löfgren syndrome

Last revised by Henry Knipe on 13 May 2020

Löfgren syndrome is a specific acute clinical presentation of systemic sarcoidosis that usually manifests with lymphadenopathy, fevers, erythema nodosum, and polyarticular arthritis. 

It is important to not confuse this syndrome with Löffler syndrome, as the names are quite similar but the conditions quite different. 

Löfgren syndrome has a strong predominance for females in their thirties 4.

It typically consists of: 

Compared to run-of-the-mill sarcoidosis, patients presenting with Löfgren syndrome typically have a better overall prognosis with a self-limited clinical course (mean ~2 months 3) and spontaneous remission.

It was initially described by Sven Halvar Löfgren (1910-1978), a Swedish physician, in 1952 2.

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