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Lymphomatoid granulomatosis

Dr Yuranga Weerakkody et al.

Lymphomatoid granulomatosis (LG) (also known as angiocentric lymphoma or angiocentric immunoproliferative lesion ⁴ ) is a rare type of non Hodgkin's Lymphoma ³. There is a recognised association with antecedant infection with the Epstein Barr virus (EBV).

It can affect a variety of organs.

lung involvement : ~ 80% of cases ⁴
skin (cutaneous) involvment : 33 - 50% ^2,4
CNS involvement : 20% ².

Radiographic features are to be discussed separately.

Etymology

Initially described by Leibow et.al in 1972 ⁵

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References

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1. Wechsler RJ, Steiner RM, Israel HL et-al. Chest radiograph in lymphomatoid granulomatosis: comparison with Wegener granulomatosis. AJR Am J Roentgenol. 1984;142 (1): 79-83. AJR Am J Roentgenol (abstract) - Pubmed citation
2. Dee PM, Arora NS, Innes DJ. The pulmonary manifestations of lymphomatoid granulomatosis. Radiology. 1982;143 (3): 613-8. Radiology (abstract) - Pubmed citation
3. Mccloskey M, Catherwood M, Mcmanus D et-al. A case of lymphomatoid granulomatosis masquerading as a lung abscess. Thorax. 2004;59 (9): 818-9. doi:10.1136/thx.2003.008094 - Free text at pubmed - Pubmed citation
4. Lee JS, Tuder R, Lynch DA. Lymphomatoid granulomatosis: radiologic features and pathologic correlations. AJR Am J Roentgenol. 2000;175 (5): 1335-9. AJR Am J Roentgenol (full text) - Pubmed citation
5. Liebow AA, Carrington CR, Friedman PJ. Lymphomatoid granulomatosis. Hum. Pathol. 1972;3 (4): 457-558. - Pubmed citation