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McCune-Albright syndrome

McCune-Albright syndrome is a genetic disorder characterised by the association of:

Clinical presentation

Presentation is variable:

  • leg pain, limp, pathological fracture: ~ 75%
  • abnormal vaginal bleeding: ~25%
  • coast of Maine cafe-au-lait spots
    • predominantly on back of trunk: ~30-50%
    • often ipsilateral to bone lesions

History and etymology

The condition is named after:

  • Fuller Albright: American (US) endocrinologist (1900-1969)
  • Donovan James McCune: American (US) paediatrician (1902-1976)

See also

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