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Megalencephaly

Dr Yuranga Weerakkody and Eytan Raz et al.

Megalencephaly is defined as enlargement of part of or all of the cerebral hemispheres. It could be bilateral or unilateral.

Often polymicrogyria or agyria is found on the affected side.

Pathology

Associations

It can occur in a variety of syndromes including

Radiographic features

MRI

MRI may show a thickened cortex with ipsilateral ventricular dilatation on the side of the megalencephaly and this feature allows differential diagnosis between congenital hemimegalencephaly from other causes, such as a lesion obstructing the foramen of Monro.

See also 

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