Multiple endocrine neoplasia type I

Multiple endocrine neoplasia (MEN) type I is also known as Wermer syndrome.

Clinical presenation

Primary hyperparathyroidism is one of the commonest presentations.


Abnormality is related to a tumour suppressor gene located in chromosome 11q13. MEN type I is an autosomal dominant syndrome characterised by:

Handy mnemonics for recalling MEN type I: 

  • PPP or PiParPanc

History and etymology

It was first characterised by P Wermer et al. in 1954 3.

Treatment and prognosis

Pancreatic malignancy is the leading cause of mortality in MEN type I. 

See also

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