Multiple endocrine neoplasia type I

Multiple endocrine neoplasia (MEN) type I is also known as Wermer syndrome.

Clinical presenation

Primary hyperparathyroidism is one of the commonest presentations.

Pathology

Abnormality is related to a tumour suppressor gene located in chromosome 11q13. MEN type I is an autosomal dominant syndrome characterised by:

Handy mnemonics for recalling MEN type I: 

  • PPP or PiParPanc
Associations

History and etymology

It was first characterised by P Wermer et al. in 1954 3.

Treatment and prognosis

Pancreatic malignancy is the leading cause of mortality in MEN type I. 

See also

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Article Information:

rID: 1619
Section: Syndromes
Synonyms or Alternate Spellings:
  • MEN I
  • Wermer syndrome
  • MEN 1
  • Multiple endocrine neoplasia type 1 (MEN I)
  • Multiple endocrine neoplasia type I
  • Multiple endocrine neoplasia type 1
  • Men1
  • multiple endocrine neoplasia syndrome type 1
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