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Myelination pattern on MR imaging

Myelination of the brain during infancy progresses in an orderly and predictable fashion.

At birth only certain structures are myelinated

Subsequently different parts become myelinated, the first change is increase in T1 signal, and later decrease in T2

  • 2 - 3 months :  anterior limb of internal capsule becomes T1 bright
  • 3 months : cerebellar white matter tracts becomes T1 bright
  • 3 - 6 months : splenium of corpus callosum becomes T2 dark
  • 6 months : genu of corpus callosum becomes T1 bright
  • 8 months : subcortical white matter becomes T1 bright
  • 8 months : genu of corpus callosum becomes T2 dark
  • 11 months : anterior limb of internal capsule becomes T2 dark
  • 1 year 2 months : occipital white matter becomes T2 dark
  • 1 year 4 months : frontal white matter becomes T2 dark
  • 1 1/2 years : majority of white matter becomes T2 dark (except terminal myelination zones adjacent to frontal horns and periatrial regions)
  • 2 years :  almost all of white matter becomes T2 dark

See also

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