This site is targeted at medical and radiology professionals, contains user contributed content and material that may be confusing to a lay audience. Use of this site implies acceptance of our Terms of Use.

Neuroblastic tumours

Neuroblastic tumours arise from primitive cells of the sympathetic system and include the following entities:

These entities represent a spectrum of disease from undifferentiated and aggressive (neuroblastoma) to the well differentiated and largely quiescent (ganglioneuroma). 


The less differentiated the earlier the presentation. Thus, neuroblastomas typically occur in infants and very young children (mean age of presentation 22 months) whereas ganglioneuroblastomas and ganglioneuromas present in older children (mean age of presentation 1-10 years and 6-15 years respectively) 1


As these tumours arise from the sympathetic nervous system it is not surprising that they arise from the neck, posterior mediastinum, adrenal gland, retroperitoneum, and pelvis 1.


Prognosis matches degree of differentiation.

  • neuroblastoma
    • stage 1, 2 or 4S: 75-90% 3 year survival
    • stage 3
      • <1 year of age: 80-90% 1 year event free survival
      • >1 year of age: 50% 3 year survival
    • stage 4
      • <1 year of age: 60-75% 1 year event free survival
      • >1 year of age: 15% 3 year survival 1
  • ganglioneuroblastoma
    • intermediate prognosis
  • ganglioneuroma
    • complete resection is curative
    • no metastatic potential
    • local recurrence reported

Updating… Please wait.


Error Unable to process the form. Check for errors and try again.

Alert_accept Thank you for updating your details.