This site is targeted at medical and radiology professionals, contains user contributed content and material that may be confusing to a lay audience. Use of this site implies acceptance of our Terms of Use.

Neuroblastoma staging

Dr Frank Gaillard et al.

Staging of neuroblastoma as described by International Neuroblastoma Staging System (INSS) is for post-operative patients and mainly for prognosis. This is as follows 1

  • stage 1
    • localised tumour with complete gross excision with or without microscopic residual disease
    • contralateral and representative ipsilateral regional lymph nodes negative for disease (nodes attached to and removed with primary tumour may be positive)
  • stage 2a
    • localised tumour with incomplete gross excision
    • ipsilateral and contralateral nodes negative for tumour
  • stage 2b
    • localised tumour with complete or incomplete resection
    • positive ipsilateral (non-adherent) nodes
    • contralateral nodes negative for tumour
  • stage 3
    • unresectable lateral tumour that crosses the midline or
    • localised tumour with contralateral regional lymph node involvement
    • midline tumour with bilateral extension by infiltration or by lymph node involvement
  • stage 4S
    • <1 year of age
    • localised tumour (stage 1, 2A or 2B)
    • distant metastases confined to skin, liver and/or bone marrow
  • stage 4
    • distant metastases not fulfilling stage 4S

In the majority of cases (60-80%), patients present with stage 3 or 4 tumours 2.

Updating… Please wait.


Error Unable to process the form. Check for errors and try again.

Alert_accept Thank you for updating your details.