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Neurofibrillary tangles

Dr Frank Gaillard et al.

Neurofibrillary tangles are abnormal cytoplasmic accumulations of tau proteins, found in neuronal and glial cells of the central nervous system. They are responsible for a number of neurodegenerative disease (collectively known as taupathies) including ¹:

Neurofibrillary tangles are also a prominent feature of Alzheimer disease, which in addition demonstrates neuritic plaques (which are extracellular).