Ossification vs calcification

Last revised by Pir Abdul Ahad Aziz Qureshi on 28 Oct 2020

In discussing mineralization, many radiology textbooks use the term calcification and make no mention of ossification.

  • ossification
    • is a process of laying down new bone material. It is synonymous with bone tissue formation. 
    • bone may form in any region where there are fibroblasts, an excess of calcium and an adequate blood supply
  • calcification
    • is the process in which calcium salts build up in soft tissue, causing it to harden
    • calcifications may be classified on whether there is mineral balance or not, and the location of the calcification
    • pathological calcification is observed in any mesenchymatous tissue of low metabolism when the vascularity is further reduced by the fibrosis of trauma or infection

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