There are numerous primary pancreatic neoplasms, in part due to the mixed endocrine and exocrine components.
Classification based on function
- exocrine - ~ 99% of all primary pancreatic neoplasms
endocrine - were previously referred as islet cell tumors because they were thought to have originated from the islets of Langerhans. However, new evidence suggests that these tumors originate from pluripotential stem cells in ductal epithelium 6.
- although the great majority of both benign and malignant pancreatic neoplasms arise from pancreatic epithelial cells, mesenchymal tumors, while rare, can derive from the connective, lymphatic, vascular, and neuronal tissues of the pancreas7.
- they account for 1-2% of all pancreatic tumors and are classified according to their histologic origin7.
- ductal adenocarcinoma is by far the most common primary tumour, usually of the head (65%) and has a very poor prognosis.
cystic neoplasms are further divided into: (with some overlap)
- macrocystic - multilocular
- serous cystadenoma - usually head. 30% have a central scar
- cystic with a solid component
- macrocystic tumours can have solid component also
- generally solid
Endocrine tumours of the pancreas are divided into :
- functional - ~ 85 %
non-functional - ~ 15% :
- third most common
- 85-100% malignant
- usually larger
Account for 1-2% of all pancreatic tumors and are classified according to their histologic origin7:
Classification based on location
- serous cystadenoma
- intraductal papillary mucinous neoplasms (IPMN)
- ductal adenocarcinoma
- pancreatoblastoma (rare and in children)
Body and tail
- 1. Weissleder R, Wittenberg J, Harisinghani MG. Primer of diagnostic imaging. Mosby Inc. (2007) ISBN:0323040683. Read it at Google Books - Find it at Amazon
- 2. Kawamoto S, Horton KM, Lawler LP et-al. Intraductal papillary mucinous neoplasm of the pancreas: can benign lesions be differentiated from malignant lesions with multidetector CT? Radiographics. 25 (6): 1451-68. doi:10.1148/rg.256055036 - Pubmed citation
- 3. Sahani DV, Kadavigere R, Saokar A et-al. Cystic pancreatic lesions: a simple imaging-based classification system for guiding management. Radiographics. 25 (6): 1471-84. doi:10.1148/rg.256045161 - Pubmed citation
- 4. AmershamHeath Medcyclopaedia
- 5. Dähnert W. Radiology review manual. Lippincott Williams & Wilkins. (2003) ISBN:0781738954. Read it at Google Books - Find it at Amazon
- 6. Low G, Panu A, Millo N et-al. Multimodality imaging of neoplastic and nonneoplastic solid lesions of the pancreas. Radiographics. 31 (4): 993-1015. doi:10.1148/rg.314105731 - Pubmed citation
- 7. Ferrozzi F, Zuccoli G, Bova D et-al. Mesenchymal tumors of the pancreas: CT findings. J Comput Assist Tomogr. 24 (4): 622-7. J Comput Assist Tomogr (link) - Pubmed citation
Synonyms & Alternative Spellings
|Synonyms or Alternative Spelling||Include in Listings?|
|Neoplasms of the pancreas||✗|
|Tumours of the pancreas||✗|
|Cancers of the pancreas||✗|