Parkinson disease (PD), also known as idiopathic parkinsonism, is a neurodegenerative disease and movement disorder characterised by a resting tremor, rigidity and hypokinesia due to progressive degeneration of dopaminergic neurons in the substancia nigra.
Parkinson disease is by far the most common cause of the parkinsonian syndrome, accounting for approximately 80% of cases (the remainder being due to other neurodegenerative disease, such as Lewy body dementia) 1.
The most common form is encountered in elderly patients and is common, seen in 2-4% of all individuals older than 65 years of age.
A juvenile form of Parkinson disease is also recognised, manifesting between 20-40 years of age 1.
The majority of cases (85-90%) are sporadic, however 10-15% of patients have a positive family history 1.
Parkinson disease is classically characterised by a triad of features:
- resting tremor
- postural instability: sometimes added as a cardinal feature 3
Dementia can be a late feature. When present it is known as Parkinson disease with later developing dementia (PDD). In contrast, Lewy body dementia has cognitive impairment either preceding or at most within 12 months of clinical onset of parkinsonian symptoms 2.
Visual hallucinations are also quite common reported to occur in 6-75% of patients (most reports suggest an incidence of 25-50% ), more frequently in patients treated with dopaminergic medication 9-10.
The dopaminergic tract is predominantly affected in Parkinson disease, and histologically, it is characterised by nigrostriatal dopaminergic degeneration leading to neuronal loss in the substantia nigra pars compacta, most conspicuous in the ventrolateral tier of neurons 11. A number of other regions including parts of the basal ganglia, brainstem, autonomic nervous system and cerebral cortex 3.
At least eleven genes have been implicated in various forms of Parkinson disease 3. Interestingly depending on which genes are involved, various clinical features are more or less prominent (e.g. Kufor-Rakeb syndrome).
Even more interestingly not all mutations result in Lewy bodies. For example juvenile Parkinson disease has been linked to mutations in the PARK2 gene, which encodes for the enzyme ubiquitin ligase-L3. In normal individuals, ubiquitin ligase-L3 is involved in ubiquitination of alpha-synuclein (the main component of Lewy bodies) and allows the formation of Lewy bodies. In patients with juvenile Parkinson disease its function is impaired and the formation of Lewy bodies is impossible. This finding suggests that Lewy bodies cannot be thought of as synonymous with, and causative of Parkinson disease. Perhaps even Lewy bodies play a protective role other forms of Parkinson disease, which manifests 20-40 years later 1.
Initial imaging findings are subtle and only potentially seen on MRI. With advanced disease, non-specific generalised minor cerebral volume loss can be demonstrated.
Loss of the normal swallow tail appearance of susceptibility signal pattern in the substantia nigra on axial imaging is perhaps the most promising diagnostic sign 12. Apart from these changes, the signal intensity in substantia nigra depends on loss of neuromelanin and iron accumulation. In addition to aiding diagnosis, MRI is also used to identify features which may indicate secondary parkinsonism rather than primary disease, such as extensive small vessel ischaemic change.
Features of Parkinson disease include 1:
absent swallow tail sign
- nigrosome-1 is usually SWI hyperintense but this is lost in Parkinson disease
- reported diagnostic accuracy of over 90%
- may show loss of normal susceptibility signal drop-out of the substantia nigra and red nuclei (due to loss of melanin containing neurons)
- dot-like areas of hyperintensity in the compact part of the substantia nigra 1
- may show confluence of the normal hypointense regions of substantia nigra (due to iron accumulation) 1
- absent swallow tail sign
Recent studies with high Tesla MRI (7T) have shown promising results regarding both sensitivity and specificity 4-5.
holds tracers for both SPECT and PET with high sensitivity for assessment of presynaptic dopaminergic deficits 6,8.
Differentiation between Parkinson disease and atypic parkinsonism is also possible, with different tracers 7-8.
Treatment and prognosis
The mainstay of treatment is medical. In patients with refractory symptoms, deep brain stimulation may be useful.
History and etymology
Parkinson disease was first described by a British physician Dr James Parkinson, both in himself and five patients 1.
There is significant overlap between many neurodegenerative disease, and Parkinson disease is no exception. Clinically the differential includes 1,3:
dementia with Lewy bodies
- dementia is clinically evident before, concurrently or at most within 12 months of onset of parkinsonian symptoms 2
- multiple system atrophy (MSA)
- progressive supranuclear palsy (PSP)
- cerebrovascular disease
metabolic diseases with parkinsonian signs and symptoms: basal ganglia signal abnormalities are usually more pronounced 1
- Wilson disease
- manganese toxicity
- chronic hepatitis
Neurodegenerative diseases are legion and their classification just as protean. A useful approach is to divide them according to underlying pathological process, although even using this schema, there is much overlap and thus resulting confusion.
neurodegenerative MRI brain (an approach)
- measurements and ratios
- midbrain to pons area ratio (for PSP)
- Magnetic Resonance Parkinsonism Index (MRPI) (for PSP)
- frontal horn width to intercaudate distance ratio (FH/CC) (for Huntington disease)
- intercaudate distance to inner table width ratio (CC/IT) (for Huntington disease)
- scoring systems
- measurements and ratios
- progressive supranuclear palsy (PSP)
fronto-temporal lobar degeneration (FTLD)
- behavioural variant fronto-temporal dementia (bvFTLD)
- language variant frontotemporal dementia (lvFTLD) (primary progressive aphasia (PPA))
- corticobasal degeneration
- typical/classical Alzheimer disease
- variant (e.g. posterior cortical atrophy)
- cerebral amyloid angiopathy (CAA)
- transthyretine-associated cerebral amyloidoses
- human prion diseases (not always included as neurodegenerative)
- neuronal intranuclear hyaline inclusion disease (NIHID)
- Alzheimer disease
- spinocerebellar ataxias
- Huntington disease
- hereditary spastic paraplegia
- amyotrophic lateral sclerosis (ALS)
- clinically unclassifiable parkinsonism (CUP)
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- 12. Schwarz ST, Afzal M, Morgan PS et-al. The 'swallow tail' appearance of the healthy nigrosome - a new accurate test of Parkinson's disease: a case-control and retrospective cross-sectional MRI study at 3T. PLoS ONE. 2014;9 (4): e93814. doi:10.1371/journal.pone.0093814 - Free text at pubmed - Pubmed citation
- 13. Schwarz ST, Rittman T, Gontu V et-al. T1-weighted MRI shows stage-dependent substantia nigra signal loss in Parkinson's disease. Mov. Disord. 2011;26 (9): 1633-8. doi:10.1002/mds.23722 - Pubmed citation
Synonyms & Alternative Spellings
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|Parkinson disease (PD)||✗|
|Parkinson's disease (PD)||✗|