Phthisis bulbi

Phthisis bulbi, also known as end-stage eye, is an atrophic scarred and disorganised globe that may result from a variety of severe ocular insults. 


The globe is reduced in size (usually < 20 mm) with a thickened/folded posterior sclera. Dystrophic calcification is common, and osseous metaplasia sometimes occurs, forming what is called "intraocular bone". 


Causes of this end-stage damage include:

Treatment and prognosis

The globe is non-functioning thus the patient is blind in that eye. Enucleation +/- prosthesis insertion is performed if there is associated chronic pain or for cosmetic reasons.

Differential diagnosis

The differential includes other causes of calcification of the globe.

See also

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