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Regenerative nodules in liver

Regenerative hepatic nodules are a form of non neoplastic nodules that arise in a cirrhotic liver. This may be slightly different from the term nodular regenerative hyperplasia which are  described histopathologically as regenerative nodules with little or no hepatic fibrosis and largely healthy hepatic architecture 1.

Radiographic features


Regenerative nodules in cirrhotic liver are generally visualised as enhancing nodules surrounded by lower attenuation thin septa on CT arterial portography (CTAP) and non-enhancing nodules surrounded by enhancing fibrous septa at CT hepatic arteriography (CTHA). The latter is considered more sensitive than the former in depicting regenerative nodules 4

Siderotic regenerative nodules (containing iron) are hyperdense to liver on precontrast imaging and become isodense to liver on post contrast phases. 


About 25% of regenerative liver nodules have increased iron deposition in comparison to normal hepatocytes, which is why they may be hypointense on T2 and T2*.

They usually do not enhance or enhance less than the liver parenchyma.

See also

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