Regenerative hepatic nodules are a form of non neoplastic nodules that arise in a cirrhotic liver. This may be slightly different from the term nodular regenerative hyperplasia which are described histopathologically as regenerative nodules with little or no hepatic fibrosis and largely healthy hepatic architecture 1.
Regenerative nodules in cirrhotic liver are generally visualised as enhancing nodules surrounded by lower attenuation thin septa on CT arterial portography (CTAP) and non-enhancing nodules surrounded by enhancing fibrous septa at CT hepatic arteriography (CTHA). The latter is considered more sensitive than the former in depicting regenerative nodules 4 .
Siderotic regenerative nodules (containing iron) are hyperdense to liver on precontrast imaging and become isodense to liver on post contrast phases.
About 25% of regenerative liver nodules have increased iron deposition in comparison to normal hepatocytes, which is why they may be hypointense on T2 and T2*.
They usually do not enhance or enhance less than the liver parenchyma.
Article being written please add or edit
- 1. Gupta AA, Kim DC, Krinsky GA et-al. CT and MRI of cirrhosis and its mimics. AJR Am J Roentgenol. 2004;183 (6): 1595-601. AJR Am J Roentgenol (full text) - Pubmed citation
- 2. Xu H, Kong X, Xiong Y et-al. MR features of regenerative nodules and dysplastic nodules in the cirrhotic liver. J. Huazhong Univ. Sci. Technol. Med. Sci. 2005;25 (5): 601-3. - Pubmed citation
- 3. Lee JM, Choi BI. Hepatocellular nodules in liver cirrhosis: MR evaluation. Abdom Imaging. 2011;36 (3): 282-9. doi:10.1007/s00261-011-9692-2 - Pubmed citation
- 4. Lim JH, Kim EY, Lee WJ et-al. Regenerative nodules in liver cirrhosis: findings at CT during arterial portography and CT hepatic arteriography with histopathologic correlation. Radiology. 1999;210 (2): 451-8. Radiology (full text) - Pubmed citation
Synonyms & Alternative Spellings
|Synonyms or Alternative Spelling||Include in Listings?|
|Regenerative hepatic nodules||✗|
|Hepatic nodular regeneration||✗|
|Hepatic regenerative nodules||✗|
|Regenerative liver nodules||✗|
|Regenerative liver nodule||✗|
|Regenerative hepatic nodule||✗|