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Retroperitoneal liposarcoma

retroperiotoneal liposarcoma is a sub type of liposarcoma, a malignant tumour of mesenchymal origin that may arise in any fat-containing region of the body. It is one of the most common primary retroperitoneal neoplasms.2

There are five histological types:

  • well-differentiated : ~ 54 % : low grade
    • lipoma-like
    • inflammatory
    • sclerosing
  • myxoid : ~ 31% : low to intermediate grade
  • pleomarphic : high grade
  • round cell : high grade
  • dedifferentiated : high grade

Metastatic disease is haematogenous and the extent of metastases is related to the histological grade of the tumour.

Radiographic features

CT
  • heterogenous mass
  • varying amount of fat and soft tissue
  • multiple septae
  • enhancing soft tissue components
MRI
  • myxoid : hyperintense on T2WI with delayed post-contrast enhancement

Treatment

The primary treatment option if resection if possible. However, local recurrence is common and occurs in 2/3 of patients. This is usually a sign of imcomplete resection and highlights the difficulty in discriminating liposarcomas from normal retroperitoneal fat.

Differential diagnosis

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