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Rhabdomyosarcoma staging

Staging of rhabdomyosarcoma is based on the Lawrence/Gehan Staging System which comprises of a combination of pretreatment staging and postoperative clinical grouping.

Stage

  • stage I : orbit, eyelid, head and neck (excluding parameningeal), genitourinary (non-bladder, non-prostate), N0 or 1, M0
  • stage II : bladder, prostate, extremity, trunk, parameningeal, other, < 5 cm, N0, M0
  • stage III : Bladder, prostate, extremity, trunk, parameningeal, other, > 5 cm, N0 or 1, M0
  • stage IV : all others, any N, M1

IRS group postsurgical pathologic grouping

  • group I
    • Ia : confined to organ of origin or muscle, completely resected (clear margins, negative regional nodes)
    • Ib : local extension beyond to organ or muscle of origin, completely resected (clear margins, negative regional nodes)
  • group II
    • IIa : microscopic disease remaining at margins : negative regional nodes
    • IIb : positive regional nodes : negative margins
    • IIc : microscopic disease remaining at margins and positive regional nodes
  • group III : incomplete resection or biopsy findings indicating gross residual disease
  • group IV : distant metastases

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