Rosenthal fibres
Rosenthal fibres are astrocytic cytoplasmic inclusions, typically found in areas of longstanding gliosis. These elongated or "cork screw" structures occur within astrocytic processes, and stain brightly (pink) on the H & E stain.
They can be seen with the following conditions:
- regions of longstanding gliosis
- around cysts and vascular malformations 1
- tumours : juvenile pilocytic astrocytoma (JPA)
- metabolic conditions : Alexander disease

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