Sialolithiasis is most common disease of salivary glands, accounting for approximately 50% of all major salivary gland pathology 5. The submandibular salivary gland is most commonly affected (80-90% of cases) with almost all the remaining cases located in the parotid duct 1-2,5.
Sialolithiasis is a disease of adults, typically between 30 and 60 years of age. There is a male predilection 5.
Typically patient presents with a history of recurrent swelling and pain in the involved gland usually associated with eating due to obstructions of the draining duct, e.g. submandibular duct, thus slowing down or disabling flow of saliva. This in turn predisposes infection of the gland proximal to the obstruction, resulting in bacterial sialoadenitis.
In chronic cases of obstruction the gland undergoes fatty atrophy and becomes asymptomatic, unless secondarily infected.
Radiologic methods used to evaluate these stones include :
Not all stones are radiopaque. Plain radiography is able to visualise only 80-90% of submandibular stones and approximately 60% of parotid duct stones, presumably due to differences in the composition of the secretion of the parent glands 2-3. Oblique views are often required to project the stones away from adjacent bone and teeth.
Sialography excels at delineating the exact size and location of stones with in salivary gland ducts. The stone will be visualised as a filling defect within the duct. In some cases contrast will not be able to pass beyond the stone.
If active infection is suspected sialography is however contraindicated due to the risk of exacerbating the extent of infection 2.
Ultrasonography is well-established in cases of clinical suspicion of sialolithiasis, able not only to visualise the stone in many instance but also the gland 2-3. Stones appear as strongly hyperechoic lines or points with distal acoustic shadowing represent stones. Small stones (< 2 mm) may however not shadow 2-3. Ultrasound is able to visualise stones that are radiolucent.
In acute obstructive cases the gland appears enlarged and excretory ducts proximal to the stone may be visibly dilated.
Examination is best performed with small high frequency intra-oral probes 5.
CT is excellent at visualising stones both within the duct and within the gland. The spacial resolution is not as high as plain radiography and as such very small stones may not be evident.
Additionally CT is able to assess the gland, although not as well as MRI (see below). In acute obstructive cases the gland may appear enlarged, hyperdense and associated with stranding and enhancement following contrast administration.
In chronic cases fatty atrophy will be evident, with the parenchyma reduced in volume and replaced by fat.
MRI is able not only to visualise larger stones but able in many instances to map the ductal anatomy and to asses the gland 2,4.
Stones appear as low signal regions (on all sequences) outlined by high signal saliva on T2 weighted images 2.
MRI is able to distinguish acute from chronic obstruction as well as glands with only incomplete obstruction 1.
In the acute setting glands are enlarged and demonstrate inflammatory changes:
- T1 - reduced signal compared to the other side
- T2 - increased signal (best seen on fat suppressed sequences)
In chronic cases, the gland is reduced in size and demonstrates fatty atrophy 1 :
- T1 - increased signal compared to the other side
- T2 - reduced signal of gland parenchyma which is itself reduced in amount
In cases where a small non-obstructive sialolith is present, the gland may appear entirely normal.
Treatment and prognosis
In many instances conservative medical management suffices. Hydration, moist heat are helpful and NSAIDS may be beneficial. Sucking on something sour, (such as a lemon) may increase salivation and promote spontaneous expulsion of the stone.
If these measures are unsuccessful, surgical removal of the salivary stone from the duct after may be required. In chronic cases or if the stone is positioned within the parenchyma of the submandibular salivary gland, the gland may need to be excised.
Increasingly non-surgical options exist to treat symptomatic stones, including 4 :
- extracorporal sialolithotripsy
- endoscopic stone removal
- endoluminal balloon dilatation and stone extraction
The differential diagnosis really depends on the modality however in general there is little confusion as clinical presentation is relatively specific. For plain film and CT the differential is that of other calcific foci, and includes 2 :
- haemangioma / phlebolith
- atherosclerotic calcification
Filling defects on sialography may be caused by :
- injected bubble of air
- blood clot
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- 1. Sumi M, Izumi M, Yonetsu K et-al. The MR imaging assessment of submandibular gland sialoadenitis secondary to sialolithiasis: correlation with CT and histopathologic findings. AJNR Am J Neuroradiol. 1999;20 (9): 1737-43. AJNR Am J Neuroradiol (full text) - Pubmed citation
- 2. Jäger L, Menauer F, Holzknecht N et-al. Sialolithiasis: MR sialography of the submandibular duct--an alternative to conventional sialography and US? Radiology. 2000;216 (3): 665-71. Radiology (full text) - Pubmed citation
- 3. Gritzmann N. Sonography of the salivary glands. AJR Am J Roentgenol. 1989;153 (1): 161-6. AJR Am J Roentgenol (abstract) - Pubmed citation
- 4. Becker M, Marchal F, Becker CD et-al. Sialolithiasis and salivary ductal stenosis: diagnostic accuracy of MR sialography with a three-dimensional extended-phase conjugate-symmetry rapid spin-echo sequence. Radiology. 2000;217 (2): 347-58. Radiology (full text) - Pubmed citation
- 5. Witt RL. Salivary gland diseases, surgical and medical management. Thieme Medical Pub. (2006) ISBN:1588904148. Read it at Google Books - Find it at Amazon
Synonyms & Alternative Spellings
|Synonyms or Alternative Spelling||Include in Listings?|
|Salivary duct stones||✗|
|Salivary duct stone||✗|
|Salivary duct calculus||✗|