This site is targeted at medical and radiology professionals, contains user contributed content, and material that may be confusing to a lay audience. Use of this site implies acceptance of our Terms of Use.

Solitary median maxillary central incisor

Radswiki et al.

The solitary median maxillary central incisor (SMMCI) is a rare dental anomaly. It is usually considered as a minor manifestation of holoprosencephaly (HPE).

Epidemiology

It is estimated to occur in 1:50,000 live births.

Pathology

It is a complex disorder consisting of multiple, mainly midline defects of development resulting from unknown factor(s) operating in utero about the 35 - 38^th day(s) from conception. The aetiology is uncertain.

Genetics

A missense mutation in the SHH gene (I111F) at 7q36 may be associated with SMMCI ².

This article is a stub, which means it needs more content. You can contribute to Radiopaedia.org too. Just register and edit... every little bit helps.