Spindle cell hepatocellular carcinoma
Citation, DOI, disclosures and article data
At the time the article was created Matt A. Morgan had no recorded disclosures.
View Matt A. Morgan's current disclosuresAt the time the article was last revised Jeremy Jones had no recorded disclosures.
View Jeremy Jones's current disclosures- Sarcomatoid hepatocellular carcinoma
- Pseudosarcomatous hepatocellular carcinoma
- Spindle cell hepatocellular carcinoma (HCC)
- Spindle cell HCC
- Hepatocellular carcinoma with sarcomatous change
Spindle cell hepatocellular carcinoma, also called sarcomatoid hepatocellular carcinoma, is a rare variant of hepatocellular carcinoma (HCC). These patients are reported to have low or normal AFP levels, otherwise risk factors and clinical presentation are similar to typical hepatocellular carcinoma.
On this page:
Epidemiology
The spindle cell variant occurred in ~2% of surgically resected hepatocellular carcinoma specimens 1,2.
Pathology
Spindle cell HCC is thought to arise either sporadically, or more commonly degenerate from an existing HCC secondary to therapies such as transcatheter arterial chemoembolisation (TACE), radiofrequency (RF) ablation, or percutaneous ethanol injection 2.
Histology
A variable percentage of the tumor contains spindle-shaped cells forming interlacing bundles. This is thought to represent sarcomatous differentiation of hepatocellular carcinoma.
Radiographic features
Currently, there are no specific imaging features and cases are diagnosed retrospectively. Refer on the main article of HCC for a broad discussion on imaging features of this condition.
ADVERTISEMENT: Supporters see fewer/no ads
Treatment and prognosis
There is no standard treatment. The difference between typical hepatocellular carcinoma and the spindle cell variant is uncertain, but prognosis is thought to be poor, partly because metastasis is thought to be more common in the spindle cell variant 1.
References
- 1. Maeda T, Adachi E, Kajiyama K et-al. Spindle cell hepatocellular carcinoma. A clinicopathologic and immunohistochemical analysis of 15 cases. Cancer. 1996;77 (1): 51-7. doi:10.1002/(SICI)1097-0142(19960101)77:1<51::AID-CNCR10>3.0.CO;2-7 - Pubmed citation
- 2. Yoshida N, Midorikawa Y, Kajiwara T et-al. Hepatocellular Carcinoma with Sarcomatoid Change without Anticancer Therapies. Case Rep Gastroenterol. 2013;7 (1): 169-74. doi:10.1159/000350558 - Free text at pubmed - Pubmed citation
- 3. Liver-directed therapy for primary and metastatic liver tumors. Springer. ISBN:0792375238. Read it at Google Books - Find it at Amazon
Incoming Links
Related articles: Pathology: Hepato-Pancreato-Biliary
- liver
- depositional disorders
- infection and inflammation
- liver abscess
- hepatic hydatid infection
- cirrhosis
- hepatitis
- cholecystitis
- cholangitis
- malignancy
- liver and intrahepatic bile duct tumors
- benign epithelial tumors
- hepatocellular hyperplasia
- hepatocellular adenoma
- hepatic/biliary cysts
- benign nonepithelial tumors
- primary malignant epithelial tumors
- hepatocellular carcinoma
- hepatocellular carcinoma variants
-
cholangiocarcinoma
- intra-hepatic
- mass-forming type
- periductal infiltrating type - Klatskin tumors
- intraductal growing type
- extra-hepatic/large duct type
- intra-hepatic
- biliary cystadenocarcinoma
- combined hepatocellular and cholangiocarcinoma
- hepatoblastoma
- undifferentiated carcinoma
- primary malignant nonepithelial tumors
- hematopoietic and lymphoid tumors
- primary hepatic lymphoma
- hepatic myeloid sarcoma (hepatic chloroma)
- secondary tumors
- miscellaneous
- adrenal rest tumors
- hepatic carcinosarcoma
- hepatic fibroma
- hepatic hemangioma
- hepatic Kaposi sarcoma
- hepatic lipoma
- hepatic mesenchymal hamartoma
- hepatic myxoma
- hepatic rhabdoid tumor
- hepatic solitary fibrous tumor
- hepatic teratoma
- hepatic yolk sac tumor
- inflammatory myofibroblastic tumor (inflammatory pseudotumor)
- nodular regenerative hyperplasia
- pancreatic rest tumors
- primary hepatic carcinoid
- benign epithelial tumors
- liver and intrahepatic bile duct tumors
- metabolic
- trauma
-
vascular and perfusion disorders
- portal vein related
- hepatic artery related
- hepatic veins related
- inferior vena cava related
- other
- third inflow
- liver thrombotic angiitis
- infra diaphragmatic total anomalous pulmonary venous return (TAPVR)
- hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease)
- pancreas
-
pancreatic neoplasms
- cystic neoplasm (cystic pancreatic mass differential diagnosis)
- solid neoplasm
- non-epithelial pancreatic neoplasms
- others
- simple pancreatic cyst
-
pancreatitis (mnemonic for the causes)
- acute pancreatitis
- chronic pancreatitis
- Ascaris-induced pancreatitis
- tropical pancreatitis
- autoimmune pancreatitis
- emphysematous pancreatitis
- hypertriglyceridemia-induced pancreatitis
- hereditary pancreatitis
- pancreatitis associated with cystic fibrosis
- pancreaticopleural fistula
- segmental pancreatitis
- pancreatic atrophy
- pancreatic lipomatosis
- pancreatic trauma
- pancreatic transplant
-
pancreatic neoplasms
- gallbladder and biliary
- congenital malformations and anatomical variants
- gallstones
- gallbladder inflammation
- bile ducts inflammation
- gallbladder wall abnormalities
- other gallbladder abnormalities
- bile duct dilatation (differential)
- bile duct wall thickening (differential)
- bile ducts neoplasms