Splenomegaly is a term which refers to enlargement of the spleen. The normal adult splenic length upper limit is usually around 12 - 15 cms.
The shape and orientation of a spleen makes accurate linear measurement difficult. On sonographic assessment, a length of 12 cms is generally considered the upper limit of normal.
The causes of splenomegaly are protean, and can be thought of under an number of headings.
- haematological disease
- storage diseases / metabolic diseases
- neoplastic (non-haematologic)
- connective tissue disorders
- neoplastic / proliferative / redistribution of haematopoesis
- cirrhosis : portal hypertension (common)
- congestive splenomegaly (Banti syndrome)
- splenic vein obstruction
- portal vein obstruction
- right heart failure
- parasitic disease
Storage diseases / metabolic / infiltrative disorders
- Gaucher disease
- glycogen storage disease
- Niemann-Pick disease
- lymphoma : (common)
- metastases (breast, lung, colon, ovary, melanoma)
Connective tissue disorders
- rheumatoid arthritis
- systemic lupus erythematosus (SLE)
* = may cause massive splenomegaly 3
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- 1. Weissleder R, Wittenberg J, Harisinghani MG et-al. Primer of diagnostic imaging. Mosby Inc. (2007) ISBN:0323040683. Read it at Google Books - Find it at Amazon
- 2. Reeder MM, Felson B. Reeder and Felson's gamuts in radiology, comprehensive lists of roentgen differential diagnosis. Springer Verlag. (2003) ISBN:0387955887. Read it at Google Books - Find it at Amazon
- 3. Taylor AJ, Dodds WJ, Erickson SJ et-al. CT of acquired abnormalities of the spleen. AJR Am J Roentgenol. 1991;157 (6): 1213-9. AJR Am J Roentgenol (abstract) - Pubmed citation
Synonyms & Alternative Spellings
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|Enlargement of the spleen||✗|