This site is targeted at medical and radiology professionals, contains user contributed content and material that may be confusing to a lay audience. Use of this site implies acceptance of our Terms of Use.

Staging of retinoblastoma

A number of systems have been devised to stage retinoblastoma, with various end-points, and multiple systems are often used concurrently. 

The Reese Ellsworth classification is assessed with fundoscopy and aims at predicting the chance of preserving the eye with external beam radiotherapy 3.

More relevant to radiology practice is the International retinoblastoma classification which predicts overall survival 1-4.

  • Stage 0: patients treated conservatively
  • Stage I: eye enucleated, completely resected histologically
  • Stage II: eye enucleated, microscopic residual tumour
  • Stage III: regional extension
    • A: overt orbital disease
    • B: preauricular or cervical lymph node extension
  • Stage IV: metastatic disease
    • A: haematogeneous metastasis without CNS involvement
      • single lesion
      • multiple lesions
    • B: CNS metastatic involvement
      1. prechiasmatic lesion
      2. CNS mass
      3. leptomeningeal disease

Updating… Please wait.


Error Unable to process the form. Check for errors and try again.

Alert_accept Thank you for updating your details.