Tuberculomas or tuberculous granulomas are well defined focal masses that result from Mycobacterium tuberculosis infection, and are one of more severe morphological forms of tuberculous disease. Tuberculomas most commonly occur in the brain (see: CNS tuberculosis) and the lung (see: pulmonary tuberculosis).


Macroscopically, a tuberculoma is a well defined firm nodule. Histologically it consists of a central core of caseating necrosis with a surrounding wall of a granulomatous reaction containing Langhans giant cells, epithelioid histiocytes and lymphocytes.

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