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Tuberculomas or tuberculous granulomas are a well defined focal mass that results from Mycobacterium tuberculosis infection, and is one of several morphological forms of tuberculous disease. Tuberculomas occur most commonly in the brain (see: CNS tuberculosis) and the lung (see: pulmonary tuberculosis).


Macroscopically, a tuberculoma is a well defined firm nodule. Histologically it consists of a central core of caseating necrosis with a surrounding wall of a granulomatous reaction containing Langhans giant cells, epithelioid histiocytes and lymphocytes.

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