Uterine artery embolisation (UAE) is a interventional radiological technique to occlude the arterial supply to the uterus. It is performed for various reasons.
Uterine artery embolisation has been practiced over more than 20 years for controlling haemorrhage following delivery / abortion, in ectopic or cervical pregnancy, gestational trophoblastic disease or carcinoma cervix.
The technique was first reported as an effective intervention for fibroids in 1995, when Ravina et al noted that several women with symptomatic leiomyomata who underwent UAE as a pre-hysterectomy treatment had significant clinical improvement to an extent that hysterectomy was no longer required.
It is now estimated that more than 100,000 UAE procedures may have been performed so far for treatment of fibroids.
- intramural fibroids
- dysfunctional uterine bleeding
- others less common indications include
Patients with fibroids, and their related problems, probably present the largest group who is most able to benefit from percutaneous treatment. Presently people with uterine fibroids traditionally undergo total abdominal, vaginal or laparoscopic assisted hysterectomies around the world. The figure in the United States is about 60000 hysterectomies per year. In less developed and more populous countries like India, the numbers may be even higher. There is an increasing need for non invasive or less invasive alternatives for uterine fibroids and dysfunctional bleeding.
- contraindications to angiography
- severe anaphylactoid reaction to contrast media
- uncorrectable coagulopathy
- severe renal insufficiency
- active pelvic infection
- prior pelvic radiation
- connective tissue disease
- prior surgery with adhesions (relative)
- thorough evaluation of patients symptoms and signs in consultation with a gynaecologist
- pelvic ultrasound and MRI
- pap smear and endometrial biopsy
- relevant history of other medical problems
Any catheter suitable for contralateral and ipsilateral uterine artery cannulation
- Robertson uterine catheter (RUC) : commonly used selective catheter for pelvic angiography
- Cobra glidecath : can also be used
- right internal mammary catheter : may be used, but less common
If the above mentioned catheters are not available, bilateral common femoral artery puncture is an option with contralateral access to the uterine arteries.
The type of embolic agent selected will depend on the indication.
- PVA (300 - 350 microns)
- post-partum haemorrhage / vaginal bleeding
- gel foam particles
- coils (occasionally)
- n-butyl-cyanoacrylate (glue)
- IV Fluids
- local anaesthesia
The IV fluids, analgesia, anti-emetics and antibiotics also need to be continued during post procedure.
- angiography complications
- post-embolisation syndrome
- uterine artery dissection / rupture
For vaginal bleeding
- alleviates need for obstetric / emergency hysterectomy
- resumption of menstruation
- successful pregnancy after UAE for PPH
- unsuspected abnormalities treated during UAE for PPH
- menorrhagia / dysmenorrhoea and metrorrhagia improve in > 70 - 95% of cases
- hospital stay is rarely > 48 hours
- patients are often back to work within 10 days
- no post laparotomy complications
- mean uterine volume reduction by 26 - 59 %
- fibroid volume reduction by 40 - 75 % (at end of 6 months)
- the overall complication rate is at ~ 10% with major complications at ~ 1.5%
- ACOG in 2008 issued guidelines that patient with fibroids can be given an option of UAE
- NICE(UK) : in 2007 recommended UAE with surgery as a first line treatment option
- 1. ACOG Practice Bulletin Number 96 August 20008
- 3. Spies JB, Spector A, Roth AR et-al. Complications after uterine artery embolization for leiomyomas. Obstet Gynecol. 2002;100 (5 Pt 1): 873-80. - Pubmed citation
- 3. Pron G, Mocarski E, Bennett J et-al. Pregnancy after uterine artery embolization for leiomyomata: the Ontario multicenter trial. Obstet Gynecol. 2005;105 (1): 67-76. doi:10.1097/01.AOG.0000149156.07061.1f - Pubmed citation
- 4. Miller CE. Modern Management of Abnormal Uterine Bleeding. Informa HealthCare. (2008) ISBN:0415454794. Read it at Google Books - Find it at Amazon
- 5. Hehenkamp WJ, Volkers NA, Birnie E et-al. Symptomatic uterine fibroids: treatment with uterine artery embolization or hysterectomy--results from the randomized clinical Embolisation versus Hysterectomy (EMMY) Trial. Radiology. 2008;246 (3): 823-32. doi:10.1148/radiol.2463070260 - Pubmed citation
- 6. Polat P, Suma S, Kantarcý M et-al. Color Doppler US in the evaluation of uterine vascular abnormalities. Radiographics. 22 (1): 47-53. Radiographics (full text) - Pubmed citation
- 7. Nizard J, Barrinque L, Frydman R et-al. Fertility and pregnancy outcomes following hypogastric artery ligation for severe post-partum haemorrhage. Hum. Reprod. 2003;18 (4): 844-8. doi:10.1093/humrep/deg161 - Pubmed citation
- 8. Spielmann AL, Keogh C, Forster BB et-al. Comparison of MRI and sonography in the preliminary evaluation for fibroid embolization. AJR Am J Roentgenol. 2006;187 (6): 1499-504. doi:10.2214/AJR.05.1476 - Pubmed citation
- Martin, J., Bhanot, K., & Athreya, S. (2012). Complications and Reinterventions in Uterine Artery Embolization for Symptomatic Uterine Fibroids: A Literature Review and Meta Analysis. CardioVascular and Interventional Radiology. doi:10.1007/s00270-012-0505-y
Synonyms & Alternative Spellings
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|Uterine artery embolization||✓|
|Uterine artery embolisation (UAE)||✗|
|Uterine arterial embolisation (UAE)||✗|