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WHO histological classification of tumours of the uterine cervix

Dr Jeremy Jones and Dr Yuranga Weerakkody et al.

The WHO histological classification is a detailed classification of tumours of the uterine cervix. It is as follows

epithelial tumours
- squamous tumours and precursors
  - squamous cell carcinoma, not otherwise specified - 8070/3
    - keratinizing - 8071/3
    - non-keratinizing - 8072/3
    - basaloid - 8083/3
    - verrucous - 8051/3
    - warty - 8051/3
    - papillary - 8052/3
    - lymphoepithelioma-like - 8082/3
  - squamotransitional carcinoma of cervix - 8120/3
  - early invasive (microinvasive) squamous cell carcinoma - 8076/3
  - squamous intraepithelial neoplasia of cervix
  - cervical intraepithelial neoplasia (CIN 3) - 8077/2
  - cervical squamous cell carcinoma in situ - 8070/2
  - benign squamous cell lesions
- glandular tumours and precursors
  - adenocarcinoma of cervix - 8140/3
    - mucinous adenocarcinoma of cervix - 8480/3
      - endocervical - 8482/3
      - intestinal - 8144/3
      - signet-ring cell - 8490/3
      - minimal deviation - 8480/3
      - villoglandular - 8262/3
    - endometrioid adenocarcinoma of cervix - 8380/3
    - clear cell adenocarcinoma of cervix - 8310/3
    - serous adenocarcinoma of cervix - 8441/3
    - mesonephric adenocarcinoma of cervix - 9110/3
  - early invasive adenocarcinoma of cervix - 8140/3
  - cervical adenocarcinoma in situ - 8140/2
  - glandular dysplasia
    - benign glandular lesions
      - Müllerian papilloma of cervix - 8560/3
      - endocervical polyp - 8015/3
  - other epithelial tumours - 8015/3
  - neuroendocrine tumours
    - carcinoid - primary cervical - 8240/3
    - atypical carcinoid - primary cervical - 8249/3
    - small cell carcinoma of the cervix - 8041/3
    - large cell neuroendocrine carcinoma of cervix - 8013/3
  - undifferentiated carcinoma of cervix - 8020/3
mesenchymal tumours and tumour-like conditions
- leiomyosarcoma of cervix - 8890/3
- endometrioid stromal sarcoma, low grade - 8931/3
- undifferentiated endocervical sarcoma - 8805/3
- sarcoma botryoides - 8910/3
- alveolar soft part sarcoma of cervix - 9581/3
- cervical angiosarcoma - 9120/3
- malignant peripheral nerve sheath tumour of cervix - 9540/3
- cervical leiomyoma - 8890/0
- genital rhabdomyoma - 8905/0
- postoperative spindle cell nodule - cervix
mixed epithelial and mesenchymal tumours
- carcinosarcoma of cervix (malignant Müllerian mixed tumour) - 8980/3
- adenosarcoma of cervix - 8933/3
- cervical Wilms tumour - 8960/3
- cervical adenofibroma - 9013/0
- cervical adenomyoma - 8932/0
melanocytic tumours
- primary cervical malignant melanoma - 8720/3
- blue naevus of cervix - 8780/0
miscellaneous tumours
- tumours of germ cell type
  - yolk sac tumour of cervix - 9071/3
  - dermoid cyst of cervix - 9084/0
  - mature cystic teratoma of cervix - 9080/0
lymphoid and haematopoetic
- malignant lymphoma - cervical lymphoma (specify type)
- cervical leukaemia (specify type)
secondary tumours

References

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1. Internet publication : http://screening.iarc.fr/atlasclassifwho.php
2. Strategies IW, Cancer IA. Cervix Cancer Screening. Iarc. (2005) ISBN:9283230108. Read it at Google Books - Find it at Amazon