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Wolf-Hirschhorn syndrome

Dr Yuranga Weerakkody and Radswiki et al.

The Wolf-Hirschhorn syndrome (WHS) is an extremely rare chromosomal anomaly characterised by partial delection of the p arm of chromosome 4 (4p16.3).

Clinicopatholigical spectrum

CNS
craniofacial
- calvarial asymmetry
- cleft lip + / - palate
conductive hearing loss
growth
- intra-uterine growth restriction (IUGR) : can be severe
cardiac anomalies
urogenital anomlaies
- hypospadias
- cryptorchidism
skeletal / limb anomalies
- club foot

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