Xanthomatous meningioma
Updates to Synonym Attributes
Updates to Article Attributes
Xanthomatous meningiomas are rare histological variants of meningiomas grouped into the subtype of metaplastic meningiomas, being WHO grade I tumours. They are characterised by cells with a lipid-filled vacuolated cytoplasm.
Although reported numbers are too small to confirm that this is definitely the case (less than 10 reported cases 1), they appear to share similar epidemiology, clinical presentation and treatment and prognosis as other meningiomas, and thus these features are not repeated here.
Epidemiology
The number of xanthomatous meningiomas fully documented is still small, no favored age group or gender were identified, with reported cases in children, adults and elderly patients 1,3.
Pathology
Metaplastic meningiomas are characterised by tumour cells sharing the characteristics of tissues from other parts of the body. In the case of xanthomatous meningiomas, they show an extensive xanthomatous change in their cells together with the characteristic features of meningothelial meningiomas 1-3. As these cells are positive for the epithelial membrane antigen (EMA), they can be differentiated from macrophages 1.
Radiographic features
CT
- differing from the conventional meningiomas, they tend to be hypodense on non-contrasted CT images due to the lipid content 4
-<p><strong>Xanthomatous meningiomas</strong> are rare histological variants of meningiomas grouped into the subtype of <a title="Metaplastic meningioma" href="/articles/metaplastic-meningioma">metaplastic meningiomas</a>, being <a title="WHO classification of CNS tumours" href="/articles/cns-tumours-classification-and-grading-who">WHO grade I</a> tumours. They are characterised by cells with a lipid-filled vacuolated cytoplasm.</p><p>Although reported numbers are too small to confirm that this is definitely the case, they appear to share similar epidemiology, clinical presentation and treatment and prognosis as other <a title="Meningiomas" href="/articles/meningioma">meningiomas</a>, and thus these features are not repeated here. </p><p> </p>- +<p><strong>Xanthomatous meningiomas</strong> are rare histological variants of meningiomas grouped into the subtype of <a href="/articles/metaplastic-meningioma">metaplastic meningiomas</a>, being <a href="/articles/cns-tumours-classification-and-grading-who">WHO grade I</a> tumours. They are characterised by cells with a lipid-filled vacuolated cytoplasm.</p><p>Although reported numbers are too small to confirm that this is definitely the case (less than 10 reported cases <sup>1</sup>), they appear to share similar clinical presentation and treatment and prognosis as other <a href="/articles/meningioma">meningiomas</a>, and thus these features are not repeated here. </p><h4>Epidemiology</h4><p>The number of xanthomatous meningiomas fully documented is still small, no favored age group or gender were identified, with reported cases in children, adults and elderly patients <sup>1,3</sup>. </p><h4>Pathology </h4><p>Metaplastic meningiomas are characterised by tumour cells sharing the characteristics of tissues from other parts of the body. In the case of xanthomatous meningiomas, they show an extensive xanthomatous change in their cells together with the characteristic features of meningothelial meningiomas <sup>1-3</sup>. As these cells are positive for the epithelial membrane antigen (EMA), they can be differentiated from macrophages <sup>1</sup>. </p><h4>Radiographic features</h4><h5>CT</h5><ul><li>differing from the conventional meningiomas, they tend to be hypodense on non-contrasted CT images due to the lipid content <sup>4</sup>
- +</li></ul>
References changed:
- 1. Ishida M, Fukami T, Nitta N et-al. Xanthomatous meningioma: a case report with review of the literature. Int J Clin Exp Pathol. 2014;6 (10): 2242-6. <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796249">Free text at pubmed</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/24133605">Pubmed citation</a><span class="auto"></span>
- 4. Katayama Y, Tsubokawa T, Tanaka A et-al. Neuroradiology. 1993;35 (3): . <a href="http://dx.doi.org/10.1007/BF00588490">doi:10.1007/BF00588490</a><span class="auto"></span>
- 2. Ikota H, Nakazato Y. A case of metaplastic meningioma with extensive xanthomatous change. Neuropathology. 2008;28 (4): 422-6. <a href="http://dx.doi.org/10.1111/j.1440-1789.2008.00865.x">doi:10.1111/j.1440-1789.2008.00865.x</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/18410275">Pubmed citation</a><span class="auto"></span>
- 3. Ijiri R, Tanaka Y, Hara M et-al. Radiation-associated xanthomatous meningioma in a child. Childs Nerv Syst. 2000;16 (5): 304-8. <a href="http://dx.doi.org/10.1007/s003810050519">doi:10.1007/s003810050519</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/10883374">Pubmed citation</a><span class="auto"></span>
Systems changed:
- Central Nervous System
Unable to process the form. Check for errors and try again.