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The zebra stripe sign occurs where children with osteogenesis imperfecta have been treated with cyclical bisphosphonate therapy, e.g. pamidronate. When the drug is delivered in cycles, dense bone is formed while treatment is being given. This results in dense stripes across the metaphyses of bones which can be visualised radiographically.
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- 1. Al Muderis, M., Azzopardi, T., Cundy, P. "Zebra Lines of Pamidronate Therapy in Children" J Bone Joint Surg Am 2007 89: 1511-1516
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