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Zebra stripe sign

Dr MT Niknejad and Dr Michael Sargent et al.

The zebra stripe sign occurs where children with osteogenesis imperfecta have been treated with cyclical bisphosphonate therapy, e.g. pamidronate. When the drug is delivered in cycles, dense bone is formed while treatment is being given. This results in dense stripes across the metaphyses of bones which can be visualised radiographically. 

Differential diagnosis

See also

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