Acute haemorrhagic leukoencephalitis
2 week history of lower respiratory tract infection. 3 days confusion and visual changes. Now left hemiplegia.
Loading more images...
Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys
Loading Stack -
0 images remaining
CT Brain : Day 1
Initial CT Brain demonstrates diffuse cerebral white matter hypoattnuation including involvement of the corpus callosum. There is associated generalised cerebral sulcal effacement. Brain biopsy was performed the following day showing acute haemorrhagic leukoencephalitis (see path report below)
CT Brain 4 days later shows interval progression of the white matter hypoattenuation and the development of basal cistern effacement (descending transtentorial herniation) from raised intracranial pressure.
Urgent decompressive bilateral fronto-temporal craniectomies were performed. CT Brain 9 days following the initial presentation shows established bilateral posterior cerebral artery territory infarcts as a result of the previous descending transtentorial herniation.
MICROSCOPIC DESCRIPTION: Sections show white matter, within which there is patchy areas within which here appears to be myelin loss in association with a moderately florid neutrophilic infiltrate which in areas is perivascular centric in association with red cell extravasation and scattered reactive changes in oligodendrocytes. No viral inclusions are identified. There is no significant lymphocytic infiltrate.
DIAGNOSIS: Deep white matter - features in keeping with acute haemorrhagic leucoencephalitis within the early stage of the spectrum of acute demyelinating encephalomyelitis (ADEM).